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Circadian and chemotherapy-related changes in urinary modified nucleosides excretion in patients with metastatic colorectal cancer

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Dulong, S., Huang, Qi, Innominato, P. F., Karaboue, A., Bouchahda, M., Pruvost, A., Théodoro, F., Agrofoglio, L. A., Adam, R., Finkenstädt, Bärbel and Lévi, Francis A. (2021) Circadian and chemotherapy-related changes in urinary modified nucleosides excretion in patients with metastatic colorectal cancer. Scientific Reports, 11 (1). 24015. doi:10.1038/s41598-021-03247-2 ISSN 2045-2322.

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Official URL: https://doi.org/10.1038/s41598-021-03247-2

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Abstract

Urinary levels of modified nucleosides reflect nucleic acids turnover and can serve as non-invasive biomarkers for monitoring tumour circadian dynamics, and treatment responses in patients with metastatic colorectal cancer. In 39 patients, median overnight urinary excretion of LC-HRMS determinations of pseudouridine, was ~ tenfold as large as those of 1-methylguanosine, 1-methyladenosine, or 4-acetylcytidine, and ~ 100-fold as large as those of adenosine and cytidine. An increase in any nucleoside excretion after chemotherapy anticipated plasma carcinoembryonic antigen progression 1–2 months later and was associated with poor survival. Ten fractionated urines were collected over 2-days in 29 patients. The median value of the rhythm-adjusted mean of urinary nucleoside excretion varied from 64.3 for pseudouridine down to 0.61 for cytidine. The rhythm amplitudes relative to the 24-h mean of 6 nucleoside excretions were associated with rest duration, supporting a tight link between nucleosides turnover and the rest-activity rhythm. Moreover, the amplitude of the 1-methylguanosine rhythm was correlated with the rest-activity dichotomy index, a significant predictor of survival outcome in prior studies. In conclusion, urinary excretion dynamics of modified nucleosides appeared useful for the characterization of the circadian control of cellular proliferation and for tracking early responses to treatments in colorectal cancer patients.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Science > Statistics
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Colon (Anatomy) -- Cancer -- Tumors -- Diagnosis, Rectum -- Cancer -- Tumors -- Diagnosis, Nucleosides -- Synthesis , CEA (Oncology), Tumor antigens
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group UK
ISSN: 2045-2322
Official Date: 14 December 2021
Dates:
DateEvent
14 December 2021Published
1 November 2021Accepted
Volume: 11
Number: 1
Article Number: 24015
DOI: 10.1038/s41598-021-03247-2
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 7 February 2022
Date of first compliant Open Access: 8 February 2022
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
ANR-10-TECS-0004 2011-2015[ANR] Agence Nationale de la Recherchehttp://dx.doi.org/10.13039/501100001665
MR/M013170[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265

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