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Circadian and chemotherapy-related changes in urinary modified nucleosides excretion in patients with metastatic colorectal cancer
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Dulong, S., Huang, Qi, Innominato, P. F., Karaboue, A., Bouchahda, M., Pruvost, A., Théodoro, F., Agrofoglio, L. A., Adam, R., Finkenstädt, Bärbel and Lévi, Francis A. (2021) Circadian and chemotherapy-related changes in urinary modified nucleosides excretion in patients with metastatic colorectal cancer. Scientific Reports, 11 (1). 24015. doi:10.1038/s41598-021-03247-2 ISSN 2045-2322.
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WRAP-Circadian-chemotherapy-related-changes-urinary-modified-nucleosides-excretion-patients-metastatic-colorectal-cancer-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1593Kb) | Preview |
Official URL: https://doi.org/10.1038/s41598-021-03247-2
Abstract
Urinary levels of modified nucleosides reflect nucleic acids turnover and can serve as non-invasive biomarkers for monitoring tumour circadian dynamics, and treatment responses in patients with metastatic colorectal cancer. In 39 patients, median overnight urinary excretion of LC-HRMS determinations of pseudouridine, was ~ tenfold as large as those of 1-methylguanosine, 1-methyladenosine, or 4-acetylcytidine, and ~ 100-fold as large as those of adenosine and cytidine. An increase in any nucleoside excretion after chemotherapy anticipated plasma carcinoembryonic antigen progression 1–2 months later and was associated with poor survival. Ten fractionated urines were collected over 2-days in 29 patients. The median value of the rhythm-adjusted mean of urinary nucleoside excretion varied from 64.3 for pseudouridine down to 0.61 for cytidine. The rhythm amplitudes relative to the 24-h mean of 6 nucleoside excretions were associated with rest duration, supporting a tight link between nucleosides turnover and the rest-activity rhythm. Moreover, the amplitude of the 1-methylguanosine rhythm was correlated with the rest-activity dichotomy index, a significant predictor of survival outcome in prior studies. In conclusion, urinary excretion dynamics of modified nucleosides appeared useful for the characterization of the circadian control of cellular proliferation and for tracking early responses to treatments in colorectal cancer patients.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Colon (Anatomy) -- Cancer -- Tumors -- Diagnosis, Rectum -- Cancer -- Tumors -- Diagnosis, Nucleosides -- Synthesis , CEA (Oncology), Tumor antigens | |||||||||
| Journal or Publication Title: | Scientific Reports | |||||||||
| Publisher: | Nature Publishing Group UK | |||||||||
| ISSN: | 2045-2322 | |||||||||
| Official Date: | 14 December 2021 | |||||||||
| Dates: |
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| Volume: | 11 | |||||||||
| Number: | 1 | |||||||||
| Article Number: | 24015 | |||||||||
| DOI: | 10.1038/s41598-021-03247-2 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 7 February 2022 | |||||||||
| Date of first compliant Open Access: | 8 February 2022 | |||||||||
| RIOXX Funder/Project Grant: |
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