Folgado, Enrique, Song, Qiao, Perrier, Sébastien, Ladmiral, Vincent and Semsarilar, Mona (2021) Fluorinated nanotubes : synthesis and self-assembly of cyclic peptide–poly(vinylidene fluoride) conjugates. Polymer Chemistry, 12 (29). pp. 4235-4243. doi:10.1039/d1py00355k ISSN 1759-9954.

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Abstract

The synthesis of cyclic peptide–poly(vinylidene fluoride) (CP–PVDF) conjugates comprising (D-alt-L)-cyclopeptides as building blocks and their self-assembly into tube-like structures is described. By growing two PVDF polymeric chains from opposite sides of a preassembled cyclic-peptide macro-chain transfer agent, a PVDF–CP–PVDF conjugate was prepared. This “grafting-from” strategy, allowed the synthesis of the conjugate with high purity and using facile purification steps. The controlled self-assembly of the conjugate from DMF or DMSO solutions was carried out by addition of THF. This triggered the aggregation process that led to formation of tube-like structures. The mean length and width of the PVDF–CP–PVDF tubes were measured using atomic force microscopy (AFM) and transmission electron microscopy (TEM). Surprisingly, the self-assembly of the CP–PVDF conjugates in DMF/THF allowed the preparation of long (up to 25 μm) tube-like structures. The formation of such long tubular peptide–polymer aggregates, based on the stacking of cyclopeptides, is unprecedented and is believed to rely on synergetic effects between the stacking of the cyclic peptide and the interactions of the fluoropolymer–peptide conjugates.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Polymers -- Analysis, Nanotubes , Fluoropolymers, Cyclic peptides -- Synthesis
Journal or Publication Title:	Polymer Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1759-9954
Official Date:	13 July 2021
Dates:	Date Event 13 July 2021 Available 6 July 2021 Accepted
Volume:	12
Number:	29
Page Range:	pp. 4235-4243
DOI:	10.1039/d1py00355k
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	16 December 2021
Date of first compliant Open Access:	25 May 2022
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID ANR-10-LABX-05-01 [ANR] Agence Nationale de la Recherche http://dx.doi.org/10.13039/501100001665 647106 European Research Council http://dx.doi.org/10.13039/501100000781 E161841 Royal Society http://dx.doi.org/10.13039/501100000288

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