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Prevalence of uncontrolled hypertension in people with comorbidities in sub-Saharan Africa : a systematic review and meta-analysis
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Mohamed, Shukri F., Uthman, Olalekan A., Mutua, Martin K., Asiki, G., Abba, Mustapha S. and Gill, Paramjit (2021) Prevalence of uncontrolled hypertension in people with comorbidities in sub-Saharan Africa : a systematic review and meta-analysis. BMJ Open, 11 (12). e045880. doi:10.1136/bmjopen-2020-045880
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WRAP-prevalence-uncontrolled-hypertension-people-comorbidities-sub-Saharan-Africa-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons: Attribution-Noncommercial 4.0. Download (1110Kb) | Preview |
Official URL: https://doi.org/10.1136/bmjopen-2020-045880
Abstract
Background: The burden of uncontrolled hypertension in sub-Saharan Africa (SSA) is high and hypertension is known to coexist with other chronic diseases such as kidney disease, diabetes among others. This is the first systematic review and meta-analysis to determine the burden of uncontrolled hypertension among patients with comorbidities in SSA. Methods: A comprehensive search was conducted on MEDLINE, Excerpta Medica Database (Embase) and Web of Science to identify all relevant articles published between 1 January 2000 and 17 June 2021. We included studies that reported on the prevalence of uncontrolled hypertension among people in SSA who report taking antihypertensive treatment and have another chronic condition. A random-effects meta-analysis was performed to obtain the pooled estimate of the prevalence of uncontrolled hypertension among patients with comorbid conditions while on treatment across studies in SSA. Results: In all, 20 articles were included for meta-analyses. Eleven articles were among diabetic patients, five articles were among patients with HIV, two were among patients with stroke while chronic kidney disease and atrial fibrillation had one article each. The pooled prevalence of uncontrolled hypertension among patients with comorbidities was 78.6% (95% CI 71.1% to 85.3%); I² 95.9%, varying from 73.1% in patients with stroke to 100.0% in patients with atrial fibrillation. Subgroup analysis showed differences in uncontrolled hypertension prevalence by various study-level characteristics Conclusion: This study suggests a high burden of uncontrolled hypertension in people with comorbidities in SSA. Strategies to improve the control of hypertension among people with comorbidities are needed. PROSPERO registration number: CRD42019108218.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | Comorbidity , Hypertension , Hypertension -- Diagnosis -- South Africa, Hypertension -- Prevention -- South Africa, Hypertension -- Epidemiology -- South Africa | ||||||||
| Journal or Publication Title: | BMJ Open | ||||||||
| Publisher: | BMJ | ||||||||
| ISSN: | 2044-6055 | ||||||||
| Official Date: | 13 December 2021 | ||||||||
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| Volume: | 11 | ||||||||
| Number: | 12 | ||||||||
| Article Number: | e045880 | ||||||||
| DOI: | 10.1136/bmjopen-2020-045880 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| RIOXX Funder/Project Grant: |
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