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Economic evaluation of disease elimination : an extension to the net-benefit framework and application to human African trypanosomiasis

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Antillon, Marina, Huang, Ching-I, Rock, Kat S. and Tediosi, Fabrizio (2021) Economic evaluation of disease elimination : an extension to the net-benefit framework and application to human African trypanosomiasis. Proceedings of the National Academy of Sciences of the United States of America, 118 (50). e2026797118. doi:10.1073/pnas.2026797118 ISSN 0027-8424.

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Official URL: https://doi.org/10.1073/pnas.2026797118

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Abstract

The global health community has earmarked a number of diseases for elimination or eradication, and these goals have often been praised on the premise of long-run cost savings. However, decision makers must contend with a multitude of demands on health budgets in the short or medium term, and costs per case often rise as the burden of a disease falls, rendering such efforts beyond the cost-effective use of scarce resources. In addition, these decisions must be made in the presence of substantial uncertainty regarding the feasibility and costs of elimination or eradication efforts. Therefore, analytical frameworks are necessary to consider the additional effort for reaching global goals, like elimination or eradication, that are beyond the cost-effective use of country resources. We propose a modification to the net-benefit framework to consider the implications of switching from an optimal strategy, in terms of cost-per-burden averted, to a strategy with a higher likelihood of meeting the global target of elimination or eradication. We illustrate the properties of our framework by considering the economic case of efforts to eliminate the transmission of gambiense human African trypanosomiasis (gHAT), a vector-borne, parasitic disease in West and Central Africa, by 2030.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Science > Mathematics
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): African trypanosomiasis , African trypanosomiasis -- Prevention -- Mathematical Models, African trypanosomiasis-- Cost effectiveness -- Mathematical Models, African trypanosomiasis -- Prevention -- Cost effectiveness
Journal or Publication Title: Proceedings of the National Academy of Sciences of the United States of America
Publisher: National Academy of Sciences
ISSN: 0027-8424
Official Date: 14 December 2021
Dates:
DateEvent
14 December 2021Published
9 December 2021Available
29 October 2021Accepted
Volume: 118
Number: 50
Article Number: e2026797118
DOI: 10.1073/pnas.2026797118
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 1 February 2022
Date of first compliant Open Access: 1 February 2022
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
OPP1177824Bill and Melinda Gates Foundationhttp://dx.doi.org/10.13039/100000865
OPP1184344Neglected Tropical Diseases (NTD) Modelling Consortiumhttps://www.ntdmodelling.org/
OPP1156227Neglected Tropical Diseases (NTD) Modelling Consortiumhttps://www.ntdmodelling.org/
OPP1186851Neglected Tropical Diseases (NTD) Modelling Consortiumhttps://www.ntdmodelling.org/
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  • https://creativecommons.org/licenses/by/...

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