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Economic evaluation of disease elimination : an extension to the net-benefit framework and application to human African trypanosomiasis
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Antillon, Marina, Huang, Ching-I, Rock, Kat S. and Tediosi, Fabrizio (2021) Economic evaluation of disease elimination : an extension to the net-benefit framework and application to human African trypanosomiasis. Proceedings of the National Academy of Sciences of the United States of America, 118 (50). e2026797118. doi:10.1073/pnas.2026797118 ISSN 0027-8424.
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WRAP-Economic-evaluation-disease-elimination-net-benefit-human-African-trypanosomiasis-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1850Kb) | Preview |
Official URL: https://doi.org/10.1073/pnas.2026797118
Abstract
The global health community has earmarked a number of diseases for elimination or eradication, and these goals have often been praised on the premise of long-run cost savings. However, decision makers must contend with a multitude of demands on health budgets in the short or medium term, and costs per case often rise as the burden of a disease falls, rendering such efforts beyond the cost-effective use of scarce resources. In addition, these decisions must be made in the presence of substantial uncertainty regarding the feasibility and costs of elimination or eradication efforts. Therefore, analytical frameworks are necessary to consider the additional effort for reaching global goals, like elimination or eradication, that are beyond the cost-effective use of country resources. We propose a modification to the net-benefit framework to consider the implications of switching from an optimal strategy, in terms of cost-per-burden averted, to a strategy with a higher likelihood of meeting the global target of elimination or eradication. We illustrate the properties of our framework by considering the economic case of efforts to eliminate the transmission of gambiense human African trypanosomiasis (gHAT), a vector-borne, parasitic disease in West and Central Africa, by 2030.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | |||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | African trypanosomiasis , African trypanosomiasis -- Prevention -- Mathematical Models, African trypanosomiasis-- Cost effectiveness -- Mathematical Models, African trypanosomiasis -- Prevention -- Cost effectiveness | |||||||||||||||
| Journal or Publication Title: | Proceedings of the National Academy of Sciences of the United States of America | |||||||||||||||
| Publisher: | National Academy of Sciences | |||||||||||||||
| ISSN: | 0027-8424 | |||||||||||||||
| Official Date: | 14 December 2021 | |||||||||||||||
| Dates: |
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| Volume: | 118 | |||||||||||||||
| Number: | 50 | |||||||||||||||
| Article Number: | e2026797118 | |||||||||||||||
| DOI: | 10.1073/pnas.2026797118 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 1 February 2022 | |||||||||||||||
| Date of first compliant Open Access: | 1 February 2022 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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