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The etiology of pneumonia from analysis of lung aspirate and pleural fluid samples : findings from the Pneumonia Etiology Research for Child Health (PERCH) Study
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(2021) The etiology of pneumonia from analysis of lung aspirate and pleural fluid samples : findings from the Pneumonia Etiology Research for Child Health (PERCH) Study. Clinical Infectious Diseases, 73 (11). e3788-e3796. doi:10.1093/cid/ciaa1032
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Official URL: https://doi.org/10.1093/cid/ciaa1032
Abstract
Background An improved understanding of childhood pneumonia etiology is required to inform prevention and treatment strategies. Lung aspiration is the gold standard specimen for pneumonia diagnostics. We report findings from analyses of lung and pleural aspirates collected in the Pneumonia Etiology Research for Child Health (PERCH) study. Methods The PERCH study enrolled children aged 1–59 months hospitalized with World Health Organization–defined severe or very severe pneumonia in 7 countries in Africa and Asia. Percutaneous transthoracic lung aspiration (LA) and pleural fluid (PF) aspiration was performed on a sample of pneumonia cases with radiological consolidation and/or PF in 4 countries. Venous blood and nasopharyngeal/oropharyngeal swabs were collected from all cases. Multiplex quantitative polymerase chain reaction (PCR) and routine microbiologic culture were applied to clinical specimens. Results Of 44 LAs performed within 3 days of admission on 622 eligible cases, 13 (30%) had a pathogen identified by either culture (5/44) or by PCR (11/29). A pathogen was identified in 12/14 (86%) PF specimens tested by either culture (9/14) or PCR (9/11). Bacterial pathogens were identified more frequently than viruses. All but 1 of the cases with a virus identified were coinfected with bacterial pathogens. Streptococcus pneumoniae (9/44 [20%]) and Staphylococcus aureus (7/14 [50%]) were the predominant pathogens identified in LA and PF, respectively. Conclusions Bacterial pathogens predominated in this selected subgroup of PERCH participants drawn from those with radiological consolidation or PF, with S. pneumoniae and S. aureus the leading pathogens identified.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||
| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Pneumonia in children, Pneumonia in children -- Diagnosis , Pleural effusions , Pneumonia -- Etiology | |||||||||
| Journal or Publication Title: | Clinical Infectious Diseases | |||||||||
| Publisher: | Oxford University Press (OUP) | |||||||||
| ISSN: | 1537-6591 | |||||||||
| Official Date: | 1 December 2021 | |||||||||
| Dates: |
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| Volume: | 73 | |||||||||
| Number: | 11 | |||||||||
| Page Range: | e3788-e3796 | |||||||||
| DOI: | 10.1093/cid/ciaa1032 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Reuse Statement (publisher, data, author rights): | ** Article version: VoR ** From Crossref journal articles via Jisc Publications Router ** History: epub 25-07-2020; issued 25-07-2020; ppub 06-12-2021. ** Licence for VoR version of this article starting on 25-07-2020: https://creativecommons.org/licenses/by/4.0/ | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: |
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