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Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas : an indicator of exposure to vector bites
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Willen, Laura, Milton, Philip, Hamley, Jonathan I. D., Walker, Martin, Osei-Atweneboana, Mike Y., Volf, Petr, Basáñez, María-Gloria and Courtenay, Orin (2022) Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas : an indicator of exposure to vector bites. PLoS Neglected Tropical Diseases, 16 (1). e0010108. doi:10.1371/journal.pntd.0010108 ISSN 1935-2727.
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Official URL: https://doi.org/10.1371/journal.pntd.0010108
Abstract
Background
In onchocerciasis endemic areas in Africa, heterogenous biting rates by blackfly vectors on humans are assumed to partially explain age- and sex-dependent infection patterns with Onchocerca volvulus. To underpin these assumptions and further improve predictions made by onchocerciasis transmission models, demographic patterns in antibody responses to salivary antigens of Simulium damnosum s.l. are evaluated as a measure of blackfly exposure.
Methodology/Principal findings
Recently developed IgG and IgM anti-saliva immunoassays for S. damnosum s.l. were applied to blood samples collected from residents in four onchocerciasis endemic villages in Ghana. Demographic patterns in antibody levels according to village, sex and age were explored by fitting generalized linear models. Antibody levels varied between villages but showed consistent patterns with age and sex. Both IgG and IgM responses declined with increasing age. IgG responses were generally lower in males than in females and exhibited a steeper decline in adult males than in adult females. No sex-specific difference was observed in IgM responses.
Conclusions/Significance
The decline in age-specific antibody patterns suggested development of immunotolerance or desensitization to blackfly saliva antigen in response to persistent exposure. The variation between sexes, and between adults and youngsters may reflect differences in behaviour influencing cumulative exposure. These measures of antibody acquisition and decay could be incorporated into onchocerciasis transmission models towards informing onchocerciasis control, elimination, and surveillance.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QL Zoology Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Simulium damnosum, Simulium damnosum -- Ghana, Simulium damnosum -- Biological control , Simuliidae, Insects as carriers of disease, Vector control , Onchocerciasis -- Ghana, Onchocerca volvulus , Salivary proteins , Immunoglobulins | ||||||
| Journal or Publication Title: | PLoS Neglected Tropical Diseases | ||||||
| Publisher: | Public Library of Science | ||||||
| ISSN: | 1935-2727 | ||||||
| Official Date: | 12 January 2022 | ||||||
| Dates: |
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| Volume: | 16 | ||||||
| Number: | 1 | ||||||
| Article Number: | e0010108 | ||||||
| DOI: | 10.1371/journal.pntd.0010108 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 23 December 2021 | ||||||
| Date of first compliant Open Access: | 23 December 2021 | ||||||
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