Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Brain signatures during reward anticipation predict persistent attention-deficit/hyperactivity disorder symptoms

Tools
- Tools
+ Tools

IMAGEN Consortium (Including:

Chen, Di, Jia, Tianye, Cheng, Wei, Cao, Miao, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Desrivières, Sylvane et al.
). (2021) Brain signatures during reward anticipation predict persistent attention-deficit/hyperactivity disorder symptoms. Journal of the American Academy of Child & Adolescent Psychiatry . doi:10.1016/j.jaac.2021.11.030 (In Press)

Research output not available from this repository, contact author.
Official URL: https://doi.org/10.1016/j.jaac.2021.11.030

Request Changes to record.

Abstract

Objective:
Children experiencing attention-deficit/hyperactivity disorder (ADHD) symptoms may retain symptoms into adulthood, but little is known about the underlying mechanism.

Method:
To identify biomarkers of persistent ADHD symptom development, we carried out whole-brain analyses of neuroimaging data during the anticipation phase of the Monetary-Incentive-Delay (MID) task in 1,368 adolescents recruited by the IMAGEN Consortium at age 14 years, whose behavioral measurements were followed up longitudinally at age 16. In particular, we focused on comparing individuals with persistent high ADHD symptoms at both ages 14 and 16 years to unaffected control individuals, but also exploring which individuals demonstrating symptom remission (with high ADHD symptoms at age 14 but much reduced at age 16).

Results:
We identified reduced activations in the medial frontal cortex and the thalamus during reward anticipation as neuro-biomarkers for persistent ADHD symptoms across time. The genetic relevance of the above findings was further supported by the associations of the polygenic risk scores of ADHD with both the persistent and control status and the activations of both brain regions. Furthermore, in an exploratory analysis, the thalamic activation might also help to distinguish persons with persistent ADHD from those remitted in both an exploratory sample (odds ratio = 9.43, p < .001) and an independent generalization sample (odds ratio = 4.64, p = .003).

Conclusion:
Using a well-established and widely applied functional magnetic resonance imaging task, we have identified neural biomarkers that could discriminate ADHD symptoms that persist throughout adolescence from controls and potentially those likely to remit during adolescent development as well.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Science > Computer Science
SWORD Depositor: Library Publications Router
Journal or Publication Title: Journal of the American Academy of Child & Adolescent Psychiatry
Publisher: Elsevier BV
ISSN: 0890-8567
Official Date: 22 December 2021
Dates:
DateEvent
22 December 2021Available
15 December 2021Accepted
DOI: 10.1016/j.jaac.2021.11.030
Status: Peer Reviewed
Publication Status: In Press
Access rights to Published version: Restricted or Subscription Access
Contributors:
ContributionNameContributor ID
Research GroupIMAGEN Consortium, UNSPECIFIED

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us