The Library
Well-defined polyacrylamides with AIE properties via rapid Cu-mediated living radical polymerization in aqueous solution : thermoresponsive nanoparticles for bioimaging
Tools
Ma, Congkai, Han, Ting, Niu, Niu, Al-Shok, Lucas, Efstathiou, Spyridon, Lester, Daniel, Huband, Steven and Haddleton, David M. (2022) Well-defined polyacrylamides with AIE properties via rapid Cu-mediated living radical polymerization in aqueous solution : thermoresponsive nanoparticles for bioimaging. Polymer Chemistry, 13 (1). pp. 58-68. doi:10.1039/d1py01432c ISSN 1759-9954.
|
PDF
WRAP-well-defined-polyacrylamides-AIE-properties-rapid-Cu-mediated-living-radical-polymerization-aqueous-solution-Haddleton-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (4Mb) | Preview |
Official URL: https://doi.org/10.1039/d1py01432c
Abstract
There is a requirement for the development of methods for the preparation of well-controlled polymers with aggregation-induced emission (AIE) properties. This requirement directed this current work towards a robust synthetic route, which would be applicable for preparation in water and the presence of many types of functional groups. Herein, aqueous Cu-mediated living radical polymerization (LRP) has been optimized to provide facile and rapid access to a diverse range of water-soluble AIE polymers at sub-ambient temperatures. Homo-, block and statistical copolymerization all proceeded to a near full monomer conversion (≥99%) within 1 or 2 h and exhibited narrow dispersity, even when DP was targeted up to 1000. This excellent control associated with this polymerisation technique and the high-end group fidelity achieved were further demonstrated by linear first order kinetics and successful in situ block copolymerization, respectively. Fine-tuning the monomer sequence and composition of poly(N-isopropylacrylamide) (PNIPAM) copolymers allows for different lower critical solution temperature (LCST) and fluorescent thermoresponsive nanoparticles, which spontaneously self-assembled to varying sizes in water as determined by a combination of techniques (DLS, SAXS and TEM). Additionally, the fluorescence intensity was demonstrated to depend on the polymer concentration, architecture of the side chains and temperature. Particularly, PNIPAM-containing polymers were resistant to reduction in thermo-induced emission. The good biocompatibility, photostability and high specificity make them promising candidates as lysosome-specific probes for application in bioimaging.
Item Type: | Journal Article | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QC Physics Q Science > QD Chemistry T Technology > TK Electrical engineering. Electronics Nuclear engineering |
|||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics |
|||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Electroluminescent devices, Photoemission, Luminescence, Thermoresponsive polymers, Nanoparticles, Nanostructured materials | |||||||||||||||
Journal or Publication Title: | Polymer Chemistry | |||||||||||||||
Publisher: | Royal Society of Chemistry | |||||||||||||||
ISSN: | 1759-9954 | |||||||||||||||
Official Date: | 2022 | |||||||||||||||
Dates: |
|
|||||||||||||||
Volume: | 13 | |||||||||||||||
Number: | 1 | |||||||||||||||
Page Range: | pp. 58-68 | |||||||||||||||
DOI: | 10.1039/d1py01432c | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 27 January 2022 | |||||||||||||||
Date of first compliant Open Access: | 31 January 2022 | |||||||||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year