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Safety of home-based exercise for people with intermittent claudication : a systematic review

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Waddell, Alexander, Seed, Sally, Broom, David R., McGregor, Gordon, Birkett, Stefan T. and Harwood, Amy E. (2022) Safety of home-based exercise for people with intermittent claudication : a systematic review. Vascular Medicine, 27 (2). pp. 186-192. doi:10.1177/1358863x211060388 ISSN 1477-0377.

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Official URL: https://doi.org/10.1177/1358863x211060388

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Abstract

Intermittent claudication (IC) is a classic symptom of peripheral artery disease, with first line treatment being supervised exercise therapy (SET). Despite this, SET is frequently underutilised, and adherence is often poor. An alternative option are home-based exercise programmes (HBEP). Although HBEPs are well tolerated, to the authors’ knowledge, no research has assessed their safety. The aim of this review was to assess the safety of HBEPs in people living with IC. We performed an electronic search of the MEDLINE, CINAHL, and Cochrane Library databases. The main parameter of interest was complication rate, calculated as the number of related adverse events per patient-hours. Subanalysis was undertaken to determine differences in safety for studies that did and did not include pre-exercise cardiac screening, and for studies with exercise at low, moderate, and high levels of claudication pain. Our search strategy identified 8693 results, of which 27 studies were included for full review. Studies included 1642 participants completing 147,810 patient-hours of home-based exercise. Four related adverse events were reported, three of which were cardiac in origin, giving an all-cause complication rate of one event per 36,953 patient-hours. Three of these events occurred following exercise to high levels of claudication pain, and one occurred with pain-free exercise. All four events occurred in studies without cardiac screening. Based on the low number of related adverse events, HBEPs appear to be a safe method of exercise prescription for people with IC. Our results strengthen the rationale for providing alternative exercise options for this population. PROSPERO Registration No.: CRD42021254581

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Intermittent claudication -- Exercise therapy -- Safety, Peripheral vascular diseases -- Exercise therapy, Arteries -- Diseases, Exercises -- Safety aspects
Journal or Publication Title: Vascular Medicine
Publisher: SAGE Publications
ISSN: 1477-0377
Official Date: 1 April 2022
Dates:
DateEvent
1 April 2022Published
20 December 2021Available
Volume: 27
Number: 2
Page Range: pp. 186-192
DOI: 10.1177/1358863x211060388
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 11 February 2022
Date of first compliant Open Access: 14 February 2022

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