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Mortality risk in people with Type 2 diabetes : a large prospective population-based cohort study (The Ayrshire Diabetes Follow-Up Cohort (ADOC) Study)
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Collier, A., Hairer, M., Cameron, L. , Ghosh, S., Boyle, J., Walters, M. and Waugh, Norman (2021) Mortality risk in people with Type 2 diabetes : a large prospective population-based cohort study (The Ayrshire Diabetes Follow-Up Cohort (ADOC) Study). Journal of Epidemiology and Public Health Reviews, 6 (1). doi:10.16966/2471-8211.209
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WRAP-mortality-risk-people-with-Type-2-diabetes-large-prospective-population-based cohort-study-Waugh-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (508Kb) | Preview |
Official URL: http://dx.doi.org/10.16966/2471-8211.209
Abstract
Background: This study investigated the effects of age, gender, socio-economic status, smoking status, hypertension, ischaemic heart disease, Body Mass Index (BMI), Glycaemic control (HbA1c) and dyslipidaemia in type 2 diabetes in a population-based analysis.
Methods: Data were collected from 46 General Practice databases in 2009 and 2014. Cox regressions were run in type 2 diabetes patients plus the non-diabetes population.
Results: Individuals with type 2 diabetes (n=16,643) had higher mortality rates than non-diabetes subjects. Ranked in order of Hazard Ratio (HR), increasing age (HR 2.31), smoking (HR 1.79), IHD (HR 1.65), deprivation (HR 1.36), hypertension (HR 1.23) and male gender (HR 1.20) all increased mortality risk (p<0.01). Statin therapy was associated with better outcome (HR 0.65, p<0.01). Abnormal lipid levels whilst not on a statin significantly increased mortality risk for raised total-cholesterol (HR 1.74) and low HDL-cholesterol (HR 1.48) but not for triglycerides (HR 0.67) (all p<0.01).
Conclusions: This large study confirmed that the all-cause mortality risk in type 2 diabetes remains elevated. We demonstrated that a man with type 2 diabetes of 5-10 years duration who smoked, had hypertension and IHD plus lived in the most deprived area had a HR of 6.2 compared with a non-smoking, normotensive, non-diabetes subject without IHD living in the least deprived area. Further research is required to understand the interaction between hypertension and type 2 diabetes plus why obesity and raised triglycerides appeared to be protective in type 2 diabetes.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Type 2 diabetes , Type 2 diabetes -- Mortality -- Scotland -- Ayrshire, Body mass index , Glycemic index , Cardiovascular system -- Diseases, Lipids -- Metabolism -- Disorders, Hypertension -- Diagnosis , Coronary heart disease -- Diagnosis | ||||||
| Journal or Publication Title: | Journal of Epidemiology and Public Health Reviews | ||||||
| Publisher: | Sci Forschen Inc | ||||||
| ISSN: | 24718211 | ||||||
| Official Date: | 31 March 2021 | ||||||
| Dates: |
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| Volume: | 6 | ||||||
| Number: | 1 | ||||||
| DOI: | 10.16966/2471-8211.209 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| RIOXX Funder/Project Grant: |
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