The Library
Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis
Tools
Tools
Tools
Tsapras, Panagiotis, Petridi, Stavroula, Chan, Selina, Geborys, Marta, Jacomin, Anne-Claire, Sagona, Antonia P., Meier, Pascal and Nezis, Ioannis P. (2022) Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis. Cell Reports, 38 (4). 110286. doi:10.1016/j.celrep.2021.110286
|
PDF
WRAP-selective-autophagy-controls-innate-immune-response-through-TAK1-TAB2-SH3PX1-axis-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (3739Kb) | Preview |
|
![[img]](http://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP-selective-autophagy-controls-innate-immune-response-through-TAK1-TAB2-SH3PX1-axis-2022.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (495Kb) |
Official URL: https://doi.org/10.1016/j.celrep.2021.110286
Abstract
Selective autophagy is a catabolic route which turns over specific cellular material for degradation by lysosomes, and whose role in the regulation of innate immunity is largely unexplored. Here, we show that the apical kinase of the Drosophila immune deficiency (IMD) pathway Tak1, as well as its co-activator Tab2, are both selective autophagy substrates that interact with the autophagy protein Atg8a. We also present a role for the Atg8a-interacting protein Sh3px1 in the downregulation of the IMD pathway, by facilitating targeting of the Tak1/Tab2 complex to the autophagy platform through its interaction with Tab2. Our findings show the Tak1/Tab2/Sh3px1 interactions with Atg8a mediate the removal of the Tak1/Tab2 signaling complex by selective autophagy. This in turn prevents constitutive activation of the IMD pathway in Drosophila. This study provides mechanistic insight on the regulation of innate immune responses by selective autophagy.
| Item Type: | Journal Article | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history Q Science > QP Physiology |
||||||||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Immune response, Cellular control mechanisms, Protein-protein interactions, Drosophila -- Physiological aspects, Cell death | ||||||||||||||||||||||||
| Journal or Publication Title: | Cell Reports | ||||||||||||||||||||||||
| Publisher: | Elsevier Inc. | ||||||||||||||||||||||||
| ISSN: | 2211-1247 | ||||||||||||||||||||||||
| Official Date: | 25 January 2022 | ||||||||||||||||||||||||
| Dates: |
|
||||||||||||||||||||||||
| Volume: | 38 | ||||||||||||||||||||||||
| Number: | 4 | ||||||||||||||||||||||||
| Article Number: | 110286 | ||||||||||||||||||||||||
| DOI: | 10.1016/j.celrep.2021.110286 | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
||||||||||||||||||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
