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ADHD symptoms and diagnosis in adult preterms : systematic review, IPD meta-analysis, and register-linkage study
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(2022) ADHD symptoms and diagnosis in adult preterms : systematic review, IPD meta-analysis, and register-linkage study. Pediatric Research . doi:10.1038/s41390-021-01929-1 (In Press)
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WRAP-ADHD-symptoms-diagnosis-adult-preterms-review-IPD-meta-analysis-register-linkage-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (843Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/s41390-021-01929-1
Abstract
Background
This study examined differences in ADHD symptoms and diagnosis between preterm and term-born adults (≥18 years), and tested if ADHD is related to gestational age, birth weight, multiple births, or neonatal complications in preterm borns.
Methods
(1) A systematic review compared ADHD symptom self-reports and diagnosis between preterm and term-born adults published in PubMed, Web of Science, and PROQUEST until April 2021; (2) a one-stage Individual Participant Data(IPD) meta-analysis (n = 1385 preterm, n = 1633 term; born 1978–1995) examined differences in self-reported ADHD symptoms[age 18–36 years]; and (3) a population-based register-linkage study of all live births in Finland (01/01/1987–31/12/1998; n = 37538 preterm, n = 691,616 term) examined ADHD diagnosis risk in adulthood (≥18 years) until 31/12/2016.
Results
Systematic review results were conflicting. In the IPD meta-analysis, ADHD symptoms levels were similar across groups (mean z-score difference 0.00;95% confidence interval [95% CI] −0.07, 0.07). Whereas in the register-linkage study, adults born preterm had a higher relative risk (RR) for ADHD diagnosis compared to term controls (RR = 1.26, 95% CI 1.12, 1.41, p < 0.001). Among preterms, as gestation length (RR = 0.93, 95% CI 0.89, 0.97, p < 0.001) and SD birth weight z-score (RR = 0.88, 95% CI 0.80, 0.97, p < 0.001) increased, ADHD risk decreased.
Conclusions
While preterm adults may not report higher levels of ADHD symptoms, their risk of ADHD diagnosis in adulthood is higher.
| Item Type: | Journal Article | ||||||
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| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||||
| Library of Congress Subject Headings (LCSH): | Attention-deficit hyperactivity disorder, Behavior disorders in children, People with mental disabilities , Developmental disabilities, Premature infants -- Development, Premature infants -- Growth , Premature infants -- Physiology , Premature infants -- Psychology | ||||||
| Journal or Publication Title: | Pediatric Research | ||||||
| Publisher: | Nature Publishing Group | ||||||
| ISSN: | 0031-3998 | ||||||
| Official Date: | 7 January 2022 | ||||||
| Dates: |
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| DOI: | 10.1038/s41390-021-01929-1 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | In Press | ||||||
| Access rights to Published version: | Open Access | ||||||
| RIOXX Funder/Project Grant: |
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