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Use of helminth therapy for management of ulcerative colitis and Crohn's disease : a systematic review

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Shields, Victoria Emma and Cooper, Jan (2022) Use of helminth therapy for management of ulcerative colitis and Crohn's disease : a systematic review. Parasitology , 149 (2). pp. 145-154. doi:10.1017/S0031182021001670

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Official URL: https://doi.org/10.1017/S0031182021001670

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Abstract

The incidence rate of inflammatory bowel diseases is increasing in developed countries. As such there is an increasing demand for new therapies. The aim of this systematic review was to investigate whether there is evidence to support the use of helminth therapy for the management of Crohn's disease and ulcerative colitis. Four databases (PubMed, Embase, Medline and the Cochrane Central Register of Control Trials) were searched for primary evidence in the form of clinical studies. Nine studies were suitable for inclusion: five double-blind randomized control trials and four open-label studies. This review divided the results of the studies into two categories: (a) the efficacy of helminth therapy and (b) the safety of helminth therapy. Results regarding the efficacy were mixed and a conclusive answer could not be reached, as there was not enough evidence to rule out a placebo effect. More research is needed, particularly studies with control groups to address the possibility of a placebo effect. Despite this, all nine studies concluded helminth therapy was safe and tolerable, and therefore there is currently no evidence against further exploration of this treatment option.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Parasitology
Publisher: Cambridge University Press
ISSN: 0031-1820
Official Date: February 2022
Dates:
DateEvent
February 2022Published
28 September 2021Available
20 September 2021Accepted
Volume: 149
Number: 2
Page Range: pp. 145-154
DOI: 10.1017/S0031182021001670
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Copyright Holders: Copyright © The Author(s), 2021. Published by Cambridge University Press

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