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Hierarchy of complex glycomacromolecules : from controlled otpologies to biomedical applications
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Zhao, Tieshuai, Terracciano, Roberto, Becker, Jonas, Monaco, Alessandra, Yilmaz, Gokhan and Becer, C. Remzi (2022) Hierarchy of complex glycomacromolecules : from controlled otpologies to biomedical applications. Biomacromolecules, 23 (3). pp. 543-575. doi:10.1021/acs.biomac.1c01294 ISSN 1526-4602.
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Official URL: https://doi.org/10.1021/acs.biomac.1c01294
Abstract
Carbohydrates bearing a distinct complexity use a special code (Glycocode) to communicate with carbohydrate-binding proteins at a high precision to manipulate biological activities in complex biological environments. The level of complexity in carbohydrate-containing macromolecules controls the amount and specificity of information that can be stored in biomacromolecules. Therefore, a better understanding of the glycocode is crucial to open new areas of biomedical applications by controlling or manipulating the interaction between immune cells and pathogens in terms of trafficking and signaling, which would become a powerful tool to prevent infectious diseases. Even though a certain level of progress has been achieved over the past decade, synthetic glycomacromolecules are still lagging far behind naturally existing glycans in terms of complexity and precision because of insufficient and inefficient synthetic techniques. Currently, specific targeting at a cellular level using synthetic glycomacromolecules is still challenging. It is obvious that multidisciplinary collaborations are essential between different specialized disciplines to enhance the carbohydrate receptor-targeting paradigm for new biomedical applications. In this Perspective, recent developments in the synthesis of sophisticated glycomacromolecules are highlighted, and their biological and biomedical applications are also discussed in detail.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Journal or Publication Title: | Biomacromolecules | ||||||||
| Publisher: | American Chemical Society (ACS) | ||||||||
| ISSN: | 1526-4602 | ||||||||
| Official Date: | 14 March 2022 | ||||||||
| Dates: |
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| Volume: | 23 | ||||||||
| Number: | 3 | ||||||||
| Page Range: | pp. 543-575 | ||||||||
| DOI: | 10.1021/acs.biomac.1c01294 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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