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Maternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children
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Girchenko, Polina, Robinson, Rachel, Rantalainen, Ville Juhani, Lahti-Pulkkinen, Marius, Heinonen-Tuomaala, Kati, Lemola, Sakari, Wolke, Dieter, Schnitzlein, Daniel, Hämäläinen, Esa, Laivuori, Hannele, Villa, Pia M., Kajantie, Eero and Räikkönen, Katri (2022) Maternal postpartum depressive symptoms partially mediate the association between preterm birth and mental and behavioral disorders in children. Scientific Reports, 12 (1). 947. doi:10.1038/s41598-022-04990-w ISSN 2045-2322.
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Official URL: https://doi.org/10.1038/s41598-022-04990-w
Abstract
Preterm birth has been linked with postpartum depressive (PPD) disorders and high symptom levels, but evidence remains conflicting and limited in quality. It remains unclear whether PPD symptoms of mothers with preterm babies were already elevated before childbirth, and whether PPD symptoms mediate/aggravate the effect of preterm birth on child mental disorders. We examined whether preterm birth associated with maternal PPD symptoms, depressive symptoms trajectories from antenatal to postpartum stage, and whether PPD symptoms mediated/aggravated associations between preterm birth and child mental disorders. Mothers of preterm (n = 125) and term-born (n = 3033) children of the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction study reported depressive symptoms four times within 8 weeks before and twice within 12 months after childbirth. Child mental and behavioral disorder diagnoses until age 8.4–12.8 years came from medical register. Preterm birth associated with higher PPD symptoms (mean difference = 0.19 SD, 95% CI 0.01, 0.37, p = 0.04), and higher odds (odds ratio = 2.23, 95% CI 1.22, 4.09, p = 0.009) of the mother to belong to a group that had consistently high depressive symptoms levels trajectory from antenatal to postpartum stage. PPD symptoms partially mediated and aggravated the association between preterm birth and child mental disorders. Preterm birth, maternal PPD symptoms and child mental disorders are associated, calling for timely prevention interventions.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | H Social Sciences > HQ The family. Marriage. Woman R Medicine > RG Gynecology and obstetrics R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Premature labor , Premature labor -- Mental illness , Prematurely born children, Mothers of prematurely born children -- Psychological aspects, Behavior disorders in children , Child psychopathology, Mentally ill children, Postpartum depression -- Diagnosis, New mothers -- Psychological aspects | ||||||||||||
| Journal or Publication Title: | Scientific Reports | ||||||||||||
| Publisher: | Nature Publishing Group UK | ||||||||||||
| ISSN: | 2045-2322 | ||||||||||||
| Official Date: | 18 January 2022 | ||||||||||||
| Dates: |
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| Volume: | 12 | ||||||||||||
| Number: | 1 | ||||||||||||
| Article Number: | 947 | ||||||||||||
| DOI: | 10.1038/s41598-022-04990-w | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Reuse Statement (publisher, data, author rights): | ** From Springer Nature via Jisc Publications Router ** History: received 02-07-2021; accepted 03-01-2022; registration 05-01-2022; pub-electronic 18-01-2022; online 18-01-2022; collection 12-2022. ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ | ||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
| Date of first compliant deposit: | 25 January 2022 | ||||||||||||
| Date of first compliant Open Access: | 26 January 2022 | ||||||||||||
| RIOXX Funder/Project Grant: |
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