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FtsK and SpoIIIE, coordinators of chromosome segregation and envelope remodeling in bacteria
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Chan, Helena, Mohamed, Ahmed M.T., Grainge, Ian and Rodrigues, Christopher D.A. (2022) FtsK and SpoIIIE, coordinators of chromosome segregation and envelope remodeling in bacteria. Trends in Microbiology, 30 (5). pp. 480-494. doi:10.1016/j.tim.2021.10.002 ISSN 0966-842X.
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Official URL: http://dx.doi.org/10.1016/j.tim.2021.10.002
Abstract
The translocation of DNA during bacterial cytokinesis is mediated by the SpoIIIE/FtsK family of proteins. These proteins ensure efficient chromosome segregation into sister cells by ATP-driven translocation of DNA and they control chromosome dimer resolution. How FtsK/SpoIIIE mediate chromosome translocation during cytokinesis in Gram-positive and Gram-negative organisms has been the subject of debate. Studies on FtsK in Escherichia coli, and recent work on SpoIIIE in Bacillus subtilis, have identified interactions between each translocase and the division machinery, supporting the idea that SpoIIIE and FtsK coordinate the final steps of cytokinesis with completion of chromosome segregation. Here we summarize and discuss the view that SpoIIIE and FtsK play similar roles in coordinating cytokinesis with chromosome segregation, during growth and differentiation.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | Trends in Microbiology | ||||||
Publisher: | Elsevier | ||||||
ISSN: | 0966-842X | ||||||
Official Date: | 1 May 2022 | ||||||
Dates: |
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Volume: | 30 | ||||||
Number: | 5 | ||||||
Page Range: | pp. 480-494 | ||||||
DOI: | 10.1016/j.tim.2021.10.002 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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