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Twelve-month cognitive trajectories in individuals at ultra-high risk for psychosis : a latent class analysis
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(2022) Twelve-month cognitive trajectories in individuals at ultra-high risk for psychosis : a latent class analysis. Schizophrenia Bulletin Open, 3 (1). sgac008. doi:10.1093/schizbullopen/sgac008 ISSN 2632-7899.
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Official URL: https://doi.org/10.1093/schizbullopen/sgac008
Abstract
Abstract Understanding longitudinal cognitive performance in individuals at ultra-high risk for psychosis (UHR) is important for informing theoretical models and treatment. A vital step in this endeavour is to determine whether there are UHR subgroups who have similar patterns of cognitive change over time. The aims were to: i) identify latent class trajectories of cognitive performance over 12-months in UHR individuals, ii) identify baseline demographic and clinical predictors of the resulting classes, and iii) determine whether trajectory classes were associated with transition to psychosis or functional outcomes. Cognition was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS) at baseline, 6- and 12-months (N=288). Using Growth Mixture Modelling, a single unimpaired improving trajectory class was observed for motor function, speed of processing, verbal fluency and BACS composite. A two-class solution was observed for executive function and working memory, showing one unimpaired and a second impaired class. A three-class solution was found for verbal learning and memory: unimpaired, mildly impaired, and initially extremely impaired, but improved (‘caught up’) to the level of the mildly impaired. IQ, omega-3 index and premorbid adjustment were associated with class membership, whereas clinical variables (symptoms, substance use), including transition to psychosis, were not. Working memory and verbal learning and memory trajectory class membership was associated with functioning outcomes. These findings suggest there is no short-term progressive cognitive decline in help-seeking UHR individuals, including those who transition to psychosis. Screening of cognitive performance may be useful for identifying UHR individuals who may benefit from targeted cognitive interventions.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Psychoses , Cognition disorders , Schizophrenia -- Diagnosis | ||||||||||||||||||||||||||||||
Journal or Publication Title: | Schizophrenia Bulletin Open | ||||||||||||||||||||||||||||||
Publisher: | Oxford University Press (OUP) | ||||||||||||||||||||||||||||||
ISSN: | 2632-7899 | ||||||||||||||||||||||||||||||
Official Date: | 13 January 2022 | ||||||||||||||||||||||||||||||
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Volume: | 3 | ||||||||||||||||||||||||||||||
Number: | 1 | ||||||||||||||||||||||||||||||
Article Number: | sgac008 | ||||||||||||||||||||||||||||||
DOI: | 10.1093/schizbullopen/sgac008 | ||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||
Reuse Statement (publisher, data, author rights): | ** Article version: AM ** From Crossref journal articles via Jisc Publications Router ** History: epub 13-01-2022; issued 13-01-2022. ** Licence for AM version of this article starting on 13-01-2022: https://creativecommons.org/licenses/by-nc/4.0/ | ||||||||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||||||||
Date of first compliant deposit: | 11 July 2022 | ||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 11 July 2022 | ||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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