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Risk-taking in humans and the medial orbitofrontal cortex reward system

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Rolls, Edmund T., Wan, Zhuo, Cheng, Wei and Feng, Jianfeng (2022) Risk-taking in humans and the medial orbitofrontal cortex reward system. NeuroImage, 249 . 118893. doi:10.1016/j.neuroimage.2022.118893

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Official URL: https://doi.org/10.1016/j.neuroimage.2022.118893

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Abstract

Risk-taking differs between humans, and is associated with the personality measures of impulsivity and sensation-seeking. To analyse the brain systems involved, self-report risk-taking, resting state functional connectivity, and related behavioral measures were analyzed in 18,740 participants of both sexes from the UK Biobank. Functional connectivities of the medial orbitofrontal cortex, ventromedial prefrontal cortex (VMPFC), and the parahippocampal areas were significantly higher in the risk-taking group (p < 0.001, FDR corrected). The risk-taking measure was validated in that it was significantly associated with alcohol drinking amount (r = 0.08, p = 5.1×10 ), cannabis use (r = 0.12, p = 6.0×10 ), and anxious feelings (r = -0.12, p = 7.6× ). The functional connectivity findings were cross-validated in two independent datasets. The higher functional connectivity of the medial orbitofrontal cortex and VMPFC included higher connectivity with the anterior cingulate cortex, which provides a route for these reward-related regions to have a greater influence on action in risk-taking individuals. In conclusion, the medial orbitofrontal cortex, which is involved in reward value and pleasure, was found to be related to risk-taking, which is associated with impulsivity. An implication is that risk-taking is driven by specific orbitofrontal cortex reward systems, and is different for different rewards which are represented differently in the brains of different individuals. This is an advance in understanding the bases and mechanisms of risk-taking in humans, given that the orbitofrontal cortex, VMPFC and anterior cingulate cortex are highly developed in humans, and that risk-taking can be reported in humans. [Abstract copyright: Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.]

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Science > Computer Science
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Prefrontal cortex, Cerebral dominance, Brain -- Localization of functions, Computational neuroscience, Brain -- Magnetic resonance imaging, Brain mapping
Journal or Publication Title: NeuroImage
Publisher: Elsevier
ISSN: 1053-8119
Official Date: 1 April 2022
Dates:
DateEvent
1 April 2022Published
8 January 2022Available
6 January 2022Accepted
Volume: 249
Article Number: 118893
DOI: 10.1016/j.neuroimage.2022.118893
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
2019YFA0709502National Key Research and Development Program of China (UNSPECIFIED
2018YFC1312904National Key Research and Development Program of ChinaUNSPECIFIED
2018SHZDZX01Science and Technology Commission of Shanghai Municipalityhttp://dx.doi.org/10.13039/501100003399
UNSPECIFIEDZhangjiang LabUNSPECIFIED
595 B18015Higher Education Discipline Innovation Projecthttp://dx.doi.org/10.13039/501100013314
82071997[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
21QA1408700Shanghai Rising-Star Programhttp://dx.doi.org/10.13039/501100013105
18ZR1404400Natural Science Foundation of Shanghaihttp://dx.doi.org/10.13039/100007219

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