The Library
Risk-taking in humans and the medial orbitofrontal cortex reward system
Tools
Tools
Tools
Rolls, Edmund T., Wan, Zhuo, Cheng, Wei and Feng, Jianfeng (2022) Risk-taking in humans and the medial orbitofrontal cortex reward system. NeuroImage, 249 . 118893. doi:10.1016/j.neuroimage.2022.118893
|
PDF
WRAP-Risk-taking-humans-medial-orbitofrontal-cortex-reward-system-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (3281Kb) | Preview |
Official URL: https://doi.org/10.1016/j.neuroimage.2022.118893
Abstract
Risk-taking differs between humans, and is associated with the personality measures of impulsivity and sensation-seeking. To analyse the brain systems involved, self-report risk-taking, resting state functional connectivity, and related behavioral measures were analyzed in 18,740 participants of both sexes from the UK Biobank. Functional connectivities of the medial orbitofrontal cortex, ventromedial prefrontal cortex (VMPFC), and the parahippocampal areas were significantly higher in the risk-taking group (p < 0.001, FDR corrected). The risk-taking measure was validated in that it was significantly associated with alcohol drinking amount (r = 0.08, p = 5.1×10 ), cannabis use (r = 0.12, p = 6.0×10 ), and anxious feelings (r = -0.12, p = 7.6× ). The functional connectivity findings were cross-validated in two independent datasets. The higher functional connectivity of the medial orbitofrontal cortex and VMPFC included higher connectivity with the anterior cingulate cortex, which provides a route for these reward-related regions to have a greater influence on action in risk-taking individuals. In conclusion, the medial orbitofrontal cortex, which is involved in reward value and pleasure, was found to be related to risk-taking, which is associated with impulsivity. An implication is that risk-taking is driven by specific orbitofrontal cortex reward systems, and is different for different rewards which are represented differently in the brains of different individuals. This is an advance in understanding the bases and mechanisms of risk-taking in humans, given that the orbitofrontal cortex, VMPFC and anterior cingulate cortex are highly developed in humans, and that risk-taking can be reported in humans. [Abstract copyright: Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.]
| Item Type: | Journal Article | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
|||||||||||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Prefrontal cortex, Cerebral dominance, Brain -- Localization of functions, Computational neuroscience, Brain -- Magnetic resonance imaging, Brain mapping | |||||||||||||||||||||||||||
| Journal or Publication Title: | NeuroImage | |||||||||||||||||||||||||||
| Publisher: | Elsevier | |||||||||||||||||||||||||||
| ISSN: | 1053-8119 | |||||||||||||||||||||||||||
| Official Date: | 1 April 2022 | |||||||||||||||||||||||||||
| Dates: |
|
|||||||||||||||||||||||||||
| Volume: | 249 | |||||||||||||||||||||||||||
| Article Number: | 118893 | |||||||||||||||||||||||||||
| DOI: | 10.1016/j.neuroimage.2022.118893 | |||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
