Low, Chen Sheng (2021) Direct comparison of 99m-technetium hepatoiminodiacetic acid (HIDA) cholescintigraphy with ultrasonography gallbladder ejection fraction assessment following fatty- meal challenge – correlation of both techniques in extrapolation towards normal values for ultrasonographic measurements in healthy subjects. MD thesis, University of Warwick.

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Abstract

Direct comparison of 99m-technetium hepatoiminodiacetic acid (hida) cholescintigraphy with ultrasonography gallbladder ejection fraction assessment following fatty- meal challenge – correlation of both techniques in extrapolation towards normal values for ultrasonographic measurements in healthy subjects

Gallbladder dyskinesia is a functional gallbladder disease which is difficult to diagnose and normally relies on several clinical and biochemical findings including imaging in the form of biliary dyskinesia. Unfortunately, the method in performing biliary scintigraphy, especially with fatty meal stimulus varies widely with no standardised practice in place.

Ultrasound assessment of the gallbladder is a well-established method for gallbladder pathology but its use in the assessment of functional disorder remains limited.

This thesis aims to study the correlation between gallbladder ejection fractions obtained from biliary scintigraphy following fatty meal stimulus. The thesis also aims to assess gallbladder contraction in healthy volunteers to possibly established normal values.

The study has demonstrated a good correlation in the assessment of gallbladder contraction between biliary scintigraphy and ultrasound for patients with biliary symptoms following a fatty meal stimulus. As published literature for this aspect is limited, the findings have further enhanced the understanding of the subject and suggests the possibility of using ultrasound as a complement modality for biliary dyskinesia assessment.

Normal range were also obtained in the healthy volunteer cohort which is wide and consistent with the findings in the published literature.

Item Type:	Thesis (MD)
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine
Library of Congress Subject Headings (LCSH):	Gallbladder -- Diseases, Food -- Fat content, Gallbladder -- Ultrasonic imaging
Official Date:	May 2021
Dates:	Date Event May 2021 UNSPECIFIED
Institution:	University of Warwick
Theses Department:	Warwick Medical School
Thesis Type:	MD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Hutchinson, Charles E. (Professor)
Format of File:	pdf
Extent:	133 leaves : illustrations
Language:	eng

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