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Cost-effectiveness of sleeping sickness elimination campaigns in five settings of the Democratic Republic of Congo
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Antillon, Marina, Huang, Ching-I, Crump, Ronald E., Brown, Paul E., Snijders, Rian, Mwamba Miaka, Erick, Keeling, Matthew James, Rock, Kat S. and Tediosi, Fabrizio (2022) Cost-effectiveness of sleeping sickness elimination campaigns in five settings of the Democratic Republic of Congo. Nature Communications, 13 . 1051. doi:10.1038/s41467-022-28598-w ISSN 2041-1723.
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Official URL: https://doi.org/10.1038/s41467-022-28598-w
Abstract
Gambiense human African trypanosomiasis (gHAT) is marked for elimination of transmission by 2030, but the disease persists in several low-income countries. We couple transmission and health outcomes models to examine the cost-effectiveness of four gHAT elimination strategies in five settings – spanning low- to high-risk – of the Democratic Republic of Congo. Alongside passive screening in fixed health facilities, the strategies include active screening at average or intensified coverage levels, alone or with vector control with a scale-back algorithm when no cases are reported for three consecutive years. In high or moderate-risk settings, costs of gHAT strategies are primarily
driven by active screening and, if used, vector control. Due to the cessation of active screening and vector control, most investments (75-80%) are made by 2030 and vector control might be cost-saving while ensuring elimination of transmission. In low-risk settings, costs are driven by passive screening, and minimum-cost strategies consisting of
active screening and passive screening lead to elimination of transmission by 2030 with high probability.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | R Medicine > RC Internal medicine | |||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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Library of Congress Subject Headings (LCSH): | African trypanosomiasis -- Prevention -- Congo (Democratic Republic), African trypanosomiasis -- Treatment -- Congo (Democratic Republic), African trypanosomiasis -- Mathematical models | |||||||||||||||||||||
Journal or Publication Title: | Nature Communications | |||||||||||||||||||||
Publisher: | Nature Publishing Group | |||||||||||||||||||||
ISSN: | 2041-1723 | |||||||||||||||||||||
Official Date: | 25 February 2022 | |||||||||||||||||||||
Dates: |
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Volume: | 13 | |||||||||||||||||||||
Article Number: | 1051 | |||||||||||||||||||||
DOI: | 10.1038/s41467-022-28598-w | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 1 February 2022 | |||||||||||||||||||||
Date of first compliant Open Access: | 28 February 2022 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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