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Visual deterioration in patients with photoreceptor loss after retinal reattachment surgery

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Rasool, Sana, Kaushik, Megha, Chaudhary, Rishika, Blachford, Karen, Berry, Martin, Scott, Robert A. H., Logan, Ann and Blanch, Richard J. (2022) Visual deterioration in patients with photoreceptor loss after retinal reattachment surgery. Graefe's Archive for Clinical and Experimental Ophthalmology . doi:10.1007/s00417-021-05519-z ISSN 0721-832X.

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Official URL: https://doi.org/10.1007/s00417-021-05519-z

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Abstract

Purpose:
Assess the relationship between photoreceptor degeneration and visual function after retinal reattachment surgery (RRS) in a prospective cohort.

Methods:
Patients with rhegmatogenous retinal detachment (RRD) were reviewed before and 6 months after vitreoretinal surgery. Optical coherence tomographical thickness of the outer nuclear layer (ONL), outer retinal segment (ORS), retinal pigmented epithelium to ellipsoid zone (RPE-EZ) and external limiting membrane to EZ (ELM-EZ) were recorded 6 months post-operatively. These were compared to best corrected visual acuity (BCVA) and retinal sensitivity (Humphrey visual field).

Results:
Thirteen macula-off and 8 macula-on RRD patients were included. The mean ONL thickness was higher after macula-on RRD compared to macula-off RRD (97.70 ± 3.62 μm vs. 73.10 ± 4.98 μm). In all RRD eyes, every 1 μm decrease in ONL thickness correlated with a 0.052 dB decrease and in retinal sensitivity and every 1 μm decrease in ORS thickness was associated with a 0.062 dB reduction in retinal sensitivity. ORS, ELM-EZ and RPE-EZ thickness did not correlate with BCVA post-RRS.

Conclusion:
There was greater ONL and ORS thinning following macula-off compared to macula-on RRD. Correlations between ONL and ORS thinning with decreased retinal sensitivity may be explained by RRD-induced photoreceptor death.

Item Type: Journal Article
Subjects: R Medicine > RE Ophthalmology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Retinal detachment, Photoreceptors, Apoptosis, Visual fields, Visual acuity
Journal or Publication Title: Graefe's Archive for Clinical and Experimental Ophthalmology
Publisher: Springer
ISSN: 0721-832X
Official Date: 26 January 2022
Dates:
DateEvent
26 January 2022Published
7 December 2021Accepted
DOI: 10.1007/s00417-021-05519-z
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 23 February 2022
Date of first compliant Open Access: 24 February 2022
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIED[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
UNSPECIFIEDSurgical Reconstruction and Microbiology Research Centrehttp://dx.doi.org/10.13039/501100013629

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