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Visual deterioration in patients with photoreceptor loss after retinal reattachment surgery
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Rasool, Sana, Kaushik, Megha, Chaudhary, Rishika, Blachford, Karen, Berry, Martin, Scott, Robert A. H., Logan, Ann and Blanch, Richard J. (2022) Visual deterioration in patients with photoreceptor loss after retinal reattachment surgery. Graefe's Archive for Clinical and Experimental Ophthalmology . doi:10.1007/s00417-021-05519-z ISSN 0721-832X.
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WRAP-visual-deterioration-patients-photoreceptor-loss-after-retinal-reattachment-surgery-Logan-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (986Kb) | Preview |
Official URL: https://doi.org/10.1007/s00417-021-05519-z
Abstract
Purpose:
Assess the relationship between photoreceptor degeneration and visual function after retinal reattachment surgery (RRS) in a prospective cohort.
Methods:
Patients with rhegmatogenous retinal detachment (RRD) were reviewed before and 6 months after vitreoretinal surgery. Optical coherence tomographical thickness of the outer nuclear layer (ONL), outer retinal segment (ORS), retinal pigmented epithelium to ellipsoid zone (RPE-EZ) and external limiting membrane to EZ (ELM-EZ) were recorded 6 months post-operatively. These were compared to best corrected visual acuity (BCVA) and retinal sensitivity (Humphrey visual field).
Results:
Thirteen macula-off and 8 macula-on RRD patients were included. The mean ONL thickness was higher after macula-on RRD compared to macula-off RRD (97.70 ± 3.62 μm vs. 73.10 ± 4.98 μm). In all RRD eyes, every 1 μm decrease in ONL thickness correlated with a 0.052 dB decrease and in retinal sensitivity and every 1 μm decrease in ORS thickness was associated with a 0.062 dB reduction in retinal sensitivity. ORS, ELM-EZ and RPE-EZ thickness did not correlate with BCVA post-RRS.
Conclusion:
There was greater ONL and ORS thinning following macula-off compared to macula-on RRD. Correlations between ONL and ORS thinning with decreased retinal sensitivity may be explained by RRD-induced photoreceptor death.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RE Ophthalmology | |||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Retinal detachment, Photoreceptors, Apoptosis, Visual fields, Visual acuity | |||||||||
| Journal or Publication Title: | Graefe's Archive for Clinical and Experimental Ophthalmology | |||||||||
| Publisher: | Springer | |||||||||
| ISSN: | 0721-832X | |||||||||
| Official Date: | 26 January 2022 | |||||||||
| Dates: |
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| DOI: | 10.1007/s00417-021-05519-z | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 23 February 2022 | |||||||||
| Date of first compliant Open Access: | 24 February 2022 | |||||||||
| RIOXX Funder/Project Grant: |
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