Xsox17 alpha and -beta mediate endoderm formation in Xenopus
UNSPECIFIED. (1997) Xsox17 alpha and -beta mediate endoderm formation in Xenopus. CELL, 91 (3). pp. 397-405. ISSN 0092-8674Full text not available from this repository.
We have isolated two Xenopus relatives of murine Sox17 expressed in gastrula presumptive endoderm. Xsox17 alpha and -beta expression can be induced in animal caps by activin, but not by FGF. Ectopic expression of these genes in animal caps induces the expression of endoderm markers; this induction is blocked by overexpression of a fusion of the Xsox17 beta HMG domain to the Drosophila Engrailed repressor domain, as is induction of endoderm markers by activin and the expression of endodermal markers in whole embryos and isolated vegetal poles. These experiments, as well as the effects of the mRNAs on embryo phenotypes, suggest that the Xsox17 genes mediate an activin-induced endoderm differentiation pathway in animal caps and are involved in normal endoderm differentiation in embryos.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
|Journal or Publication Title:||CELL|
|Official Date:||31 October 1997|
|Number of Pages:||9|
|Page Range:||pp. 397-405|
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