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Increased brain volume from higher cereal and lower coffee intake : shared genetic determinants and impacts on cognition and metabolism
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Kang, Jujiao, Jia, Tianye, Jiao, Zeyu, Shen, Chun, Xie, Chao, Cheng, Wei, Sahakian, Barbara J., Waxman, David, Prof. and Feng, Jianfeng (2022) Increased brain volume from higher cereal and lower coffee intake : shared genetic determinants and impacts on cognition and metabolism. Cerebral Cortex, 32 (22). pp. 5163-5174. doi:10.1093/cercor/bhac005 ISSN 1460-2199.
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WRAP-increased-brain-volume-higher-cereal-lower-coffee-intake-Feng-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1690Kb) | Preview |
Official URL: https://doi.org/10.1093/cercor/bhac005
Abstract
It is unclear how different diets may affect human brain development and if genetic and environmental factors play a part. We investigated diet effects in the UK Biobank data from 18,879 healthy adults and discovered anticorrelated brain-wide gray matter volume (GMV)-association patterns between coffee and cereal intake, coincidence with their anticorrelated genetic constructs. The Mendelian randomization approach further indicated a causal effect of higher coffee intake on reduced total GMV, which is likely through regulating the expression of genes responsible for synaptic development in the brain. The identified genetic factors may further affect people’s lifestyle habits and body/blood fat levels through the mediation of cereal/coffee intake, and the brain-wide expression pattern of gene CPLX3, a dedicated marker of subplate neurons that regulate cortical development and plasticity, may underlie the shared GMV-association patterns among the coffee/cereal intake and cognitive functions. All the main findings were successfully replicated. Our findings thus revealed that high-cereal and low-coffee diets shared similar brain and genetic constructs, leading to long-term beneficial associations regarding cognitive, body mass index (BMI), and other metabolic measures. This study has important implications for public health, especially during the pandemic, given the poorer outcomes of COVID-19 patients with greater BMIs.
| Item Type: | Journal Article | |||||||||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QP Physiology R Medicine > RB Pathology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Medical genetics -- Statistical methods, Gene expression , Brain -- Growth, Cognitive neuroscience | |||||||||||||||||||||||||||
| Journal or Publication Title: | Cerebral Cortex | |||||||||||||||||||||||||||
| Publisher: | Oxford University Press (OUP) | |||||||||||||||||||||||||||
| ISSN: | 1460-2199 | |||||||||||||||||||||||||||
| Official Date: | 15 November 2022 | |||||||||||||||||||||||||||
| Dates: |
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| Volume: | 32 | |||||||||||||||||||||||||||
| Number: | 22 | |||||||||||||||||||||||||||
| Page Range: | pp. 5163-5174 | |||||||||||||||||||||||||||
| DOI: | 10.1093/cercor/bhac005 | |||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
| Date of first compliant deposit: | 7 June 2022 | |||||||||||||||||||||||||||
| Date of first compliant Open Access: | 8 June 2022 | |||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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