Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Synthesis related to the antitumour agent 593A

Tools
- Tools
+ Tools

Howes, Colin (1983) Synthesis related to the antitumour agent 593A. PhD thesis, University of Warwick.

[img]
Preview
PDF
WRAP_Theses_Howes_1983.pdf - Submitted Version - Requires a PDF viewer.

Download (8Mb) | Preview
Official URL: http://webcat.warwick.ac.uk/record=b1755512

Request Changes to record.

Abstract

The natural product antibiotic 593A is useful in the treatment of some forms of cancer. However, like most of the drugs used in the treatment of cancer 593A manifests unpleasant side-effects in patients. The object of this work was to explore syntheses of 593A and its analogues. The results of the initial clinical trials on 593A, and the nature of cancer and chemotherapy are summarised briefly in the first chapter. This chapter also describes the previous attempts to prepare 593A and the synthesis strategies adopted in this work.

Chapter 2 details the technicalities involved in the experimental work.

The third and firth chapters are concerned with approaches to 593A analogues from piperazinedione derived (S)-asparagine.

The fifth chapter deals with a different synthetic strategy, starting from 2,3-diaminopropionic acid. New syntheses of 2,3-diaminopropionic acid and a number of its derivatives are described.

Chapter 6 deals with a strategy for the preparation of 593A involving a β-lactam intermediate which is popular with other workers in the field. A synthesis of (S)-3-hydroxypiperidine is described which is an important intermediate in this approach to 593A.

Item Type: Thesis (PhD)
Subjects: Q Science > QD Chemistry
Library of Congress Subject Headings (LCSH): Antibiotics, Antibiotics -- Side effects, Cancer -- Treatment, Tumors -- Treatment
Official Date: September 1983
Dates:
DateEvent
September 1983UNSPECIFIED
Institution: University of Warwick
Theses Department: Department of Chemistry
Thesis Type: PhD
Publication Status: Unpublished
Supervisor(s)/Advisor: Golding, B. T.
Sponsors: Science and Engineering Research Council (Great Britain)
Format of File: pdf
Extent: [6], xi, 187 leaves
Language: eng

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us