The Library
The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA
Tools
Roulé, Thomas, Christ, Aurelie, Hussain, Nosheen, Huang, Ying, Hartmann, Caroline, Benhamed, Moussa, Gutierrez-Marcos, José F., Ariel, Federico, Crespi, Martin and Blein, Thomas (2022) The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA. Molecular Plant, 15 (5). pp. 840-856. doi:10.1016/j.molp.2022.02.007 ISSN 1674-2052.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: https://doi.org/10.1016/j.molp.2022.02.007
Abstract
Clustered organization of biosynthetic non-homologous genes is emerging as a characteristic feature of plant genomes. The co-regulation of clustered genes seems to largely depend on epigenetic reprogramming and three-dimensional chromatin conformation. Here we identified the long noncoding RNA (lncRNA) MARneral Silencing (MARS), localized inside the Arabidopsis marneral cluster, which controls the local epigenetic activation of its surrounding region in response to ABA. MARS modulates the POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) component LIKE-HETEROCHROMATIN PROTEIN 1 (LHP1) binding throughout the cluster in a dose-dependent manner, determining H3K27me3 deposition and chromatin condensation. In response to ABA, MARS decoys LHP1 away from the cluster and promotes the formation of a chromatin loop bringing together the MARNERAL SYNTHASE 1 (MRN1) locus and a distal ABA-responsive enhancer. The enrichment of co-regulated lncRNAs in clustered metabolic genes in Arabidopsis suggests that the acquisition of novel noncoding transcriptional units may constitute an additional regulatory layer driving the evolution of biosynthetic pathways.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Molecular Plant | ||||||||
Publisher: | Cell Press | ||||||||
ISSN: | 1674-2052 | ||||||||
Official Date: | 2 May 2022 | ||||||||
Dates: |
|
||||||||
Volume: | 15 | ||||||||
Number: | 5 | ||||||||
Page Range: | pp. 840-856 | ||||||||
DOI: | 10.1016/j.molp.2022.02.007 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |