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Why are women with polycystic ovary syndrome obese?
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Barber, Thomas M. (2022) Why are women with polycystic ovary syndrome obese? British Medical Bulletin, 143 (1). pp. 4-15. ldac007. doi:10.1093/bmb/ldac007 ISSN 0007-1420.
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WRAP-Why-women-polycystic-ovary-syndrome-obese-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons: Attribution-Noncommercial 4.0. Download (336Kb) | Preview |
Official URL: https://doi.org/10.1093/bmb/ldac007
Abstract
Introduction
Polycystic ovary syndrome (PCOS) is a common condition characterized by reproductive, hyperandrogenic and dysmetabolic features, and often becomes clinically manifest during adolescence, particularly with weight-gain.
Sources of data
Pubmed search.
Areas of agreement
PCOS is heritable and closely associates with obesity (based on data from both epidemiological and genetic studies). Furthermore, insulin resistance forms a central cornerstone of the pathogenesis of PCOS and mediates a close association between obesity and the severity of the phenotypic features of PCOS.
Areas of controversy
Our understanding of the pathogenesis of PCOS remains incomplete, especially regarding its missing heritability (with only a small fraction having been identified from the genome-wide association studies reported to date), and its developmental origins.
Growing points
A challenge for the future is to explore a role for epigenetic modifications in the development of PCOS, and implications for the in utero environment and novel therapeutic opportunities.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Polycystic ovary syndrome, Obesity in women, Obesity -- Genetic aspects | ||||||||
| Journal or Publication Title: | British Medical Bulletin | ||||||||
| Publisher: | Oxford University Press | ||||||||
| ISSN: | 0007-1420 | ||||||||
| Official Date: | September 2022 | ||||||||
| Dates: |
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| Volume: | 143 | ||||||||
| Number: | 1 | ||||||||
| Page Range: | pp. 4-15 | ||||||||
| Article Number: | ldac007 | ||||||||
| DOI: | 10.1093/bmb/ldac007 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 24 March 2022 | ||||||||
| Date of first compliant Open Access: | 24 March 2022 | ||||||||
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