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Perioperative stroke : a perspective on challenges and opportunities for experimental treatment and diagnostic strategies
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Jin, Xia, Li, Peiying, Michalski, Dominik, Li, Shen, Zhang, Yueman, Jolkkonen, Jukka, Cui, Lili, Didwischus, Nadine, Xuan, Wei and Boltze, Johannes (2022) Perioperative stroke : a perspective on challenges and opportunities for experimental treatment and diagnostic strategies. CNS Neuroscience & Therapeutics, 28 (4). pp. 497-509. doi:10.1111/cns.13816 ISSN 1755-5930.
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WRAP-perioperative-stroke-perspective-challenges-opportunities-experimental-treatment-diagnostic-strategies-Boltze-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (988Kb) | Preview |
Official URL: https://doi.org/10.1111/cns.13816
Abstract
Perioperative stroke is an ischemic or hemorrhagic cerebral event during or up to 30 days after surgery. It is a feared condition due to a relatively high incidence, difficulties in timely detection, and unfavorable outcome compared to spontaneously occurring stroke. Recent preclinical data suggest that specific pathophysiological mechanisms such as aggravated neuroinflammation contribute to the detrimental impact of perioperative stroke. Conventional treatment options are limited in the perioperative setting due to difficult diagnosis and medications affecting coagulation in may cases. On the contrary, the chance to anticipate cerebrovascular events at the time of surgery may pave the way for prevention strategies. This review provides an overview on perioperative stroke incidence, related problems, and underlying pathophysiological mechanisms. Based on this analysis, we assess experimental stroke treatments including neuroprotective approaches, cell therapies, and conditioning medicine strategies regarding their potential use in perioperative stroke. Interestingly, the specific aspects of perioperative stroke might enable a more effective application of experimental treatment strategies such as classical neuroprotection whereas others including cell therapies may be of limited use. We also discuss experimental diagnostic options for perioperative stroke augmenting classical clinical and imaging stroke diagnosis. While some experimental stroke treatments may have specific advantages in perioperative stroke, the paucity of established guidelines or multicenter clinical research initiatives currently limits their thorough investigation.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Cerebrovascular disease -- Treatment, Ischemia -- Treatment, Preoperative care | |||||||||||||||
| Journal or Publication Title: | CNS Neuroscience & Therapeutics | |||||||||||||||
| Publisher: | Wiley | |||||||||||||||
| ISSN: | 1755-5930 | |||||||||||||||
| Official Date: | April 2022 | |||||||||||||||
| Dates: |
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| Volume: | 28 | |||||||||||||||
| Number: | 4 | |||||||||||||||
| Page Range: | pp. 497-509 | |||||||||||||||
| DOI: | 10.1111/cns.13816 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 15 March 2022 | |||||||||||||||
| Date of first compliant Open Access: | 18 March 2022 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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