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Altered grey matter cortical and subcortical T1-weighted/T2-weighted ratio in premature-born adults

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Schmitz-Koep, Benita, Menegaux, Aurore, Gaser, Christian, Brandes, Elin, Schinz, David, Thalhammer, Melissa, Daamen, Marcel, Boecker, Henning, Zimmer, Claus, Priller, Josef, Wolke, Dieter, Bartmann, Peter, Sorg, Christian and Hedderich, Dennis M. (2022) Altered grey matter cortical and subcortical T1-weighted/T2-weighted ratio in premature-born adults. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging . doi:10.1016/j.bpsc.2022.02.013 (In Press)

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Official URL: https://doi.org/10.1016/j.bpsc.2022.02.013

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Abstract

Background
Microscopic studies in newborns and animal models indicate impaired myelination after premature birth, particularly for cortical myelination; however, it remains unclear whether such myelination impairments last into adulthood and – if so – are relevant for impaired cognitive performance. It has been suggested that the ratio of T1w and T2w MRI signal intensity (T1w/T2w ratio) is a proxy for myelin content. We hypothesized altered grey matter (GM) T1w/T2w ratio in premature-born adults, which is associated with lower cognitive performance after premature birth.

Methods
We analyzed GM T1w/T2w ratio in 101 very premature-born adults (<32 weeks of gestation and/or birthweight <1500g, VP/VLBW) and 109 full-term controls at 26 years of age, controlled for voxel-wise volume alterations. Cognitive performance was assessed by verbal, performance, and full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale.

Results
Significantly higher T1w/T2w ratio in VP/VLBW subjects was found bilaterally in widespread cortical areas, particularly in frontal, parietal and temporal cortices, and in putamen and pallidum. In these areas, T1w/T2w ratio was not related to birth variables such as gestational age, or IQ scores. In contrast, significantly lower T1w/T2w ratio in VP/VLBW subjects was found in bilateral clusters in superior temporal gyrus which was associated with birth weight in the VP/VLBW group. Furthermore, lower T1w/T2w ratio in left superior temporal gyrus was associated with lower full-scale and verbal IQ.

Conclusions
Results demonstrate GM T1w/T2w ratio alterations in premature-born adults and suggest altered GM myelination development after premature birth with lasting and functionally relevant effects into early adulthood.

Item Type: Journal Article
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology
R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Science > Psychology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Premature labor , Prematurely born children , Brain -- Growth, Myelination , Brain -- Imaging
Journal or Publication Title: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Publisher: Elsevier
ISSN: 24519022
Official Date: 8 March 2022
Dates:
DateEvent
8 March 2022Available
28 February 2022Accepted
DOI: 10.1016/j.bpsc.2022.02.013
Status: Peer Reviewed
Publication Status: In Press
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
SO 1336/1-1[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
01ER0801 Bundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
01ER0803Bundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
733280 (RECAP)Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661
KKF 8765162Technische Universität Münchenhttp://dx.doi.org/10.13039/501100005713
KKF8700000474Technische Universität Münchenhttp://dx.doi.org/10.13039/501100005713
KK8700000620 Technische Universität Münchenhttp://dx.doi.org/10.13039/501100005713

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