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Effects of a maternal psychosocial intervention on hair derived biomarkers of HPA axis function in mothers and children in rural Pakistan
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Baranov, Victoria, Frost, Allison, Hagaman, Ashley, Simmons, Julian G., Manzoor, Muhammad S., Biroli, Pietro, Bhalotra, Sonia, Rahman, Atif, Sikander, Siham and Maselko, Joanna (2022) Effects of a maternal psychosocial intervention on hair derived biomarkers of HPA axis function in mothers and children in rural Pakistan. SSM - Mental Health, 2 . 100082. doi:10.1016/j.ssmmh.2022.100082 ISSN 2666-5603.
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WRAP-Effects-maternal-psychosocial-intervention-hair-biomarkers-HPA-axis-function-mothers-Pakistan-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (866Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.ssmmh.2022.100082
Abstract
Objective
Disruptions in the hypothalamic-pituitary-adrenal (HPA) axis are thought to be key neuroendocrine mechanisms involved in psychopathology and may have intergenerational impacts. Hair-derived HPA hormones offer a measure of long-term HPA axis activity that may be useful in assessing maternal and infant health. Building on a community-based randomized control trial of a perinatal depression intervention in Pakistan, we examine intervention effects on HPA axis activity in a subsample of mothers and infants.
Methods
HPA axis activity was assessed using hair-derived cortisol, cortisone, and dehydroepiandosterone (DHEA). Hair samples were collected from mother-child dyads at one year postpartum from prenatally depressed women randomized to a cognitive-behavioral intervention (n = 35 dyads) or to enhanced usual care (n = 37 dyads), and from a comparison sample of women who screened negative for depression in pregnancy (n = 35 dyads).
Results
The intervention group had 38 percent (p=0.01) lower maternal cortisol levels and 45 percent (p < 0.01) lower maternal cortisone compared to the EUC group. Maternal DHEA levels were higher among women in the intervention group compared to the EUC group by 29 percent (p = 0.02). Intergenerational intervention effects show higher DHEA levels in infants by 43% (p = 0.03). Infant cortisol and cortisone did not differ across groups.
Conclusions
Results suggest that the perinatal depression intervention has effects on HPA axis activity in both mothers and children, providing evidence that treating maternal depression may impact physiological stress system functioning intergenerationally. In addition, utilizing hair-derived biomarkers of HPA-axis activity is a potentially useful clinical indicator of intervention impacts on the neuroendocrine system.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RB Pathology R Medicine > RG Gynecology and obstetrics R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Social Sciences > Economics | ||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Hypothalamic-pituitary-adrenal axis , Hydrocortisone, Dehydroepiandrosterone -- Physiological effect , Postpartum depression , Postpartum depression -- Pakistan, Biochemical markers -- Diagnostic use | ||||||||||||||||||||||||
| Journal or Publication Title: | SSM - Mental Health | ||||||||||||||||||||||||
| Publisher: | Elsevier | ||||||||||||||||||||||||
| ISSN: | 2666-5603 | ||||||||||||||||||||||||
| Official Date: | December 2022 | ||||||||||||||||||||||||
| Dates: |
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| Volume: | 2 | ||||||||||||||||||||||||
| Article Number: | 100082 | ||||||||||||||||||||||||
| DOI: | 10.1016/j.ssmmh.2022.100082 | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||
| Date of first compliant deposit: | 11 March 2022 | ||||||||||||||||||||||||
| Date of first compliant Open Access: | 11 March 2022 | ||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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