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Aggregation‐induced emission featured supramolecular tubisomes for imaging‐guided drug delivery
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Yang, Jie, Yu, Xinyang, Song, Ji‐Inn, Song, Qiao, Hall, Stephen C. L., Yu, Guocan and Perrier, Sébastien (2022) Aggregation‐induced emission featured supramolecular tubisomes for imaging‐guided drug delivery. Angewandte Chemie International Edition, 61 (9). e202115208. doi:10.1002/anie.202115208 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.202115208
Abstract
Aggregation-induced emission featured cylindrical polymeric nanoparticles (tubisomes) are obtained from the hierarchical self-assembly of an amphiphilic cyclic peptide polymer conjugate. Intriguingly, encapsulation of the anticancer drug doxorubicin (DOX) can inactivate the fluorescence of both tubisome and DOX due to the energy transfer relay (ETR). The release of DOX can interrupt the ETR effect and light up the silenced fluorescence, thereby permitting the in-situ visualization of drug release.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
| Journal or Publication Title: | Angewandte Chemie International Edition | ||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||
| ISSN: | 1433-7851 | ||||||
| Official Date: | 21 February 2022 | ||||||
| Dates: |
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| Volume: | 61 | ||||||
| Number: | 9 | ||||||
| Article Number: | e202115208 | ||||||
| DOI: | 10.1002/anie.202115208 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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