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SGLT-2 inhibitors in NAFLD : expanding their role beyond diabetes and cardioprotection?
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Androutsakos, Theodoros, Nasiri-Ansari, Narjes, Bakasis, Athanasios-Dimitrios, Kyrou, Ioannis, Efstathopoulos, Efstathios, Randeva, Harpal S. and Kassi, Eva (2022) SGLT-2 inhibitors in NAFLD : expanding their role beyond diabetes and cardioprotection? International Journal of Molecular Sciences, 23 (6). e3107. doi:10.3390/ijms23063107 ISSN 1422-0067.
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Official URL: https://doi.org/10.3390/ijms23063107
Abstract
Non-alcoholic fatty liver disease (NAFLD) is an ‘umbrella’ term, comprising a spectrum ranging from benign, liver steatosis to non-alcoholic steatohepatitis, liver fibrosis and eventually cirrhosis and hepatocellular carcinoma. NAFLD has evolved as a major health problem in recent years. Discovering ways to prevent or delay the progression of NAFLD has become a global focus. Lifestyle modifications remain the cornerstone of NAFLD treatment, even though various pharmaceutical interventions are currently under clinical trial. Among them, sodium-glucose co-transporter type-2 inhibitors (SGLT-2i) are emerging as promising agents. Processes regulated by SGLT-2i, such as endoplasmic reticulum (ER) and oxidative stress, low-grade inflammation, autophagy and apoptosis are all implicated in NAFLD pathogenesis. In this review, we summarize the current understanding of the NAFLD pathophysiology, and specifically focus on the potential impact of SGLT-2i in NAFLD development and progression, providing current evidence from in vitro, animal and human studies. Given this evidence, further mechanistic studies would advance our understanding of the exact mechanisms underlying the pathogenesis of NAFLD and the potential beneficial actions of SGLT-2i in the context of NAFLD treatment.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Journal or Publication Title: | International Journal of Molecular Sciences | ||||||
Publisher: | MDPI | ||||||
ISSN: | 1422-0067 | ||||||
Official Date: | 13 March 2022 | ||||||
Dates: |
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Volume: | 23 | ||||||
Number: | 6 | ||||||
Article Number: | e3107 | ||||||
DOI: | 10.3390/ijms23063107 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 17 November 2022 | ||||||
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