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A microdosimetry application for Microbeam Radiation Therapy dose delivery using TOPAS
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Tassano-Smith, E. L., Wilkinson, E. L., Duffy, J. A. and Spiga, J. (2020) A microdosimetry application for Microbeam Radiation Therapy dose delivery using TOPAS. In: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Boston, MA, USA, 31 Oct - 07 Nov 2020. Published in: Proceedings of the IEEE Symposium on Nuclear Science (NSS/MIC) pp. 1-4. doi:10.1109/NSS/MIC42677.2020.9508039 ISSN 1082-3654.
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Official URL: http://dx.doi.org/10.1109/NSS/MIC42677.2020.950803...
Abstract
Microbeam Radiation Therapy as a cancer treatment is developing fast due to its high therapeutic effect. This work simulates the MRT setup and the multi-slit collimator used in the creation of microbeams with the aid of TOPAS. TOPAS is a Geant4-based Monte Carlo extension developed to make simulations more readily available to both research and clinical medical physicists, as well as to extend its functionality. A multi-slit collimator is modelled to produce x-ray microbeams with a width of 50 μm and a centre to centre spacing of 400 μm. The energies range from 0 to 600 keV, and they are sampled using the synchrotron-wiggler generated spectrum employed at the biomedical facility of the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This work aims to identify the accuracy of the dose deposition curves and peak to valley dose ratios (PVDRs) obtained with TOPAS. The PVDRs decreased with depth but increased prior to phantom exit due to the absence of back scattering. The simulated results are in line with published simulated and empirical findings, which suggest that TOPAS can be satisfactorily used as a tool for the calculation of the percentage depth dose and PVDRs at the energies considered in this study.
| Item Type: | Conference Item (Paper) | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||
| Journal or Publication Title: | Proceedings of the IEEE Symposium on Nuclear Science (NSS/MIC) | ||||||
| Publisher: | IEEE | ||||||
| ISSN: | 1082-3654 | ||||||
| Book Title: | 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) | ||||||
| Official Date: | 2020 | ||||||
| Dates: |
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| Page Range: | pp. 1-4 | ||||||
| DOI: | 10.1109/NSS/MIC42677.2020.9508039 | ||||||
| Status: | Not Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Copyright Holders: | IEEE | ||||||
| Conference Paper Type: | Paper | ||||||
| Title of Event: | 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) | ||||||
| Type of Event: | Conference | ||||||
| Location of Event: | Boston, MA, USA | ||||||
| Date(s) of Event: | 31 Oct - 07 Nov 2020 |
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