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Dynamic changes in brain lateralization correlate with human cognitive performance
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Wu, Xinran, Kong, Xiangzhen, Vatansever, Deniz, Liu, ZhaoWen, Zhang, Kai, Sahakian, Barbara J., Robbins, Trevor W., Feng, Jianfeng, Thompson, Paul and Zhang, Jie (2022) Dynamic changes in brain lateralization correlate with human cognitive performance. PLoS Biology, 20 (3). e3001560. doi:10.1371/journal.pbio.3001560
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WRAP-dynamic-changes-brain-lateralization-correlate-human-cognitive-performance-Feng-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (3805Kb) | Preview |
Official URL: https://doi.org/10.1371/journal.pbio.3001560
Abstract
Hemispheric lateralization constitutes a core architectural principle of human brain organization underlying cognition, often argued to represent a stable, trait-like feature. However, emerging evidence underlines the inherently dynamic nature of brain networks, in which time-resolved alterations in functional lateralization remain uncharted. Integrating dynamic network approaches with the concept of hemispheric laterality, we map the spatiotemporal architecture of whole-brain lateralization in a large sample of high-quality resting-state fMRI data (N = 991, Human Connectome Project). We reveal distinct laterality dynamics across lower-order sensorimotor systems and higher-order associative networks. Specifically, we expose 2 aspects of the laterality dynamics: laterality fluctuations (LF), defined as the standard deviation of laterality time series, and laterality reversal (LR), referring to the number of zero crossings in laterality time series. These 2 measures are associated with moderate and extreme changes in laterality over time, respectively. While LF depict positive association with language function and cognitive flexibility, LR shows a negative association with the same cognitive abilities. These opposing interactions indicate a dynamic balance between intra and interhemispheric communication, i.e., segregation and integration of information across hemispheres. Furthermore, in their time-resolved laterality index, the default mode and language networks correlate negatively with visual/sensorimotor and attention networks, which are linked to better cognitive abilities. Finally, the laterality dynamics are associated with functional connectivity changes of higher-order brain networks and correlate with regional metabolism and structural connectivity. Our results provide insights into the adaptive nature of the lateralized brain and new perspectives for future studies of human cognition, genetics, and brain disorders.
| Item Type: | Journal Article | |||||||||||||||||||||||||||||||||||||||||||||
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| Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||||||||||||||||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Cerebral dominance, Cerebral hemispheres, Brain , Cognition, Brain -- Localization of functions, Laterality | |||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | PLoS Biology | |||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | Public Library of Science | |||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1545-7885 | |||||||||||||||||||||||||||||||||||||||||||||
| Official Date: | 17 March 2022 | |||||||||||||||||||||||||||||||||||||||||||||
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| Volume: | 20 | |||||||||||||||||||||||||||||||||||||||||||||
| Number: | 3 | |||||||||||||||||||||||||||||||||||||||||||||
| Article Number: | e3001560 | |||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1371/journal.pbio.3001560 | |||||||||||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||||||||||||||||||||||||||
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