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A molecularly imprinted polymer nanoparticle-based surface plasmon resonance sensor platform for antibiotic detection in river water and milk
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Sullivan, Mark V., Henderson, Alisha., Hand, Rachel A. and Turner, Nicholas W. (2022) A molecularly imprinted polymer nanoparticle-based surface plasmon resonance sensor platform for antibiotic detection in river water and milk. Analytical and Bioanalytical Chemistry, 414 . pp. 3687-3696. doi:10.1007/s00216-022-04012-8 ISSN 1618-2642.
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WRAP-A-molecularly-imprinted-polymer-nanoparticle-based-surface-plasmon-resonance-sensor-platform-Hand-22.pdf - Accepted Version - Requires a PDF viewer. Download (582Kb) | Preview |
Official URL: https://doi.org/10.1007/s00216-022-04012-8
Abstract
Using a solid-phase molecular imprinting technique, high-affinity nanoparticles (nanoMIPs) selective for the target antibiotics, ciprofloxacin, moxifloxacin, and ofloxacin have been synthesised. These have been applied in the development of a surface plasmon resonance (SPR) sensor for the detection of the three antibiotics in both river water and milk. The particles produced demonstrated good uniformity with approximate sizes of 65.8 ± 1.8 nm, 76.3 ± 4.1 nm, and 85.7 ± 2.5 nm, and were demonstrated to have affinities of 36.2 nM, 54.7 nM, and 34.6 nM for the ciprofloxacin, moxifloxacin, and ofloxacin nanoMIPs, respectively. Cross-reactivity studies highlighted good selectivity towards the target antibiotic compared with a non-target antibiotic. Using spiked milk and river water samples, the nanoMIP-based SPR sensor offered comparable affinity with 66.8 nM, 33.4 nM, and 55.0 nM (milk) and 39.3 nM, 26.1 nM, and 42.7 nM (river water) for ciprofloxacin, moxifloxacin, and ofloxacin nanoMIPs, respectively, to that seen within a buffer standard. Estimated LODs for the three antibiotic targets in both milk and river water were low nM or below. The developed SPR sensor showed good potential for using the technology for the capture and detection of antibiotics from food and environmental samples.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QD Chemistry | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||
SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Imprinted polymers, Molecular imprinting, Nanoparticles -- Synthesis, Surface plasmon resonance, Antibiotic residues, Antibiotics -- Environmental aspects, Water -- Pollution, Milk contamination | |||||||||
Journal or Publication Title: | Analytical and Bioanalytical Chemistry | |||||||||
Publisher: | Springer | |||||||||
ISSN: | 1618-2642 | |||||||||
Official Date: | May 2022 | |||||||||
Dates: |
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Volume: | 414 | |||||||||
Page Range: | pp. 3687-3696 | |||||||||
DOI: | 10.1007/s00216-022-04012-8 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Date of first compliant deposit: | 3 May 2022 | |||||||||
Date of first compliant Open Access: | 23 March 2023 | |||||||||
RIOXX Funder/Project Grant: |
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