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Obstructive sleep apnoea and polycystic ovary syndrome : clinical interactions and underlying pathophysiology
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Kyrou, Ioannis, Kahal, Hassan, Weickert , Martin O, Barber, Thomas M. and Randeva, Harpal S. (2021) Obstructive sleep apnoea and polycystic ovary syndrome : clinical interactions and underlying pathophysiology. In: Diamanti-Kandarakis, Evanthia, (ed.) Polycystic Ovary Syndrome: challenging issues in the modern era of individualized medicine. Amsterdam ; Cambridge, MA : Elsevier, pp. 325-344. ISBN 9780128230466
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Official URL: https://www.elsevier.com/books/polycystic-ovary-sy...
Abstract
As the most frequent endocrine disorder in women of reproductive age, polycystic ovary syndrome (PCOS) poses a significant disease burden in this population. In addition, PCOS exhibits a close association with multiple cardiometabolic diseases, including obesity (particularly central), insulin resistance, and type 2 diabetes. Obstructive sleep apnea (OSA) constitutes another prevalent chronic condition, which is characterized by recurrent hypopnea/apnea episodes during sleep and also exhibits significant overlap with obesity and the metabolic syndrome. As such, PCOS and OSA are frequently observed together and in combination with other metabolic syndrome manifestations, with central obesity and insulin resistance typically constituting the common denominators that drive the underlying pathophysiology. Notably, OSA often remains underdiagnosed, particularly in women, until severe symptoms become apparent. In this context, existing clinical guidelines on the management of PCOS recommend screening for OSA in women with PCOS and increased body mass index, particularly in order to promptly identify and alleviate OSA-related symptoms. However, there is still a relatively limited number of studies on the potential interactions between PCOS and OSA and on the pathophysiologic mechanisms that link these two conditions. The present chapter presents a synthetic overview of the pertinent literature on the associations between PCOS and OSA, focusing on the relevant epidemiological evidence, key interactions, and the underlying pathophysiology.
| Item Type: | Book Item | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) | ||||||||
| Publisher: | Elsevier | ||||||||
| Place of Publication: | Amsterdam ; Cambridge, MA | ||||||||
| ISBN: | 9780128230466 | ||||||||
| Book Title: | Polycystic Ovary Syndrome: challenging issues in the modern era of individualized medicine | ||||||||
| Editor: | Diamanti-Kandarakis, Evanthia | ||||||||
| Official Date: | 25 November 2021 | ||||||||
| Dates: |
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| Number of Pages: | 350 | ||||||||
| Page Range: | pp. 325-344 | ||||||||
| DOI: | 10.1016/B978-0-12-823045-9.00029-8 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Copyright Holders: | Copyright: © Elsevier 2021 | ||||||||
| Description: | Chapter 19 |
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