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Obstructive sleep apnoea and polycystic ovary syndrome : clinical interactions and underlying pathophysiology

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Kyrou, Ioannis, Kahal, Hassan, Weickert , Martin O, Barber, Thomas M. and Randeva, Harpal S. (2021) Obstructive sleep apnoea and polycystic ovary syndrome : clinical interactions and underlying pathophysiology. In: Diamanti-Kandarakis, Evanthia, (ed.) Polycystic Ovary Syndrome: challenging issues in the modern era of individualized medicine. Amsterdam ; Cambridge, MA : Elsevier, pp. 325-344. ISBN 9780128230466

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Official URL: https://www.elsevier.com/books/polycystic-ovary-sy...

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Abstract

As the most frequent endocrine disorder in women of reproductive age, polycystic ovary syndrome (PCOS) poses a significant disease burden in this population. In addition, PCOS exhibits a close association with multiple cardiometabolic diseases, including obesity (particularly central), insulin resistance, and type 2 diabetes. Obstructive sleep apnea (OSA) constitutes another prevalent chronic condition, which is characterized by recurrent hypopnea/apnea episodes during sleep and also exhibits significant overlap with obesity and the metabolic syndrome. As such, PCOS and OSA are frequently observed together and in combination with other metabolic syndrome manifestations, with central obesity and insulin resistance typically constituting the common denominators that drive the underlying pathophysiology. Notably, OSA often remains underdiagnosed, particularly in women, until severe symptoms become apparent. In this context, existing clinical guidelines on the management of PCOS recommend screening for OSA in women with PCOS and increased body mass index, particularly in order to promptly identify and alleviate OSA-related symptoms. However, there is still a relatively limited number of studies on the potential interactions between PCOS and OSA and on the pathophysiologic mechanisms that link these two conditions. The present chapter presents a synthetic overview of the pertinent literature on the associations between PCOS and OSA, focusing on the relevant epidemiological evidence, key interactions, and the underlying pathophysiology.

Item Type: Book Item
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Publisher: Elsevier
Place of Publication: Amsterdam ; Cambridge, MA
ISBN: 9780128230466
Book Title: Polycystic Ovary Syndrome: challenging issues in the modern era of individualized medicine
Editor: Diamanti-Kandarakis, Evanthia
Official Date: 25 November 2021
Dates:
DateEvent
25 November 2021Published
13 July 2022Available
11 April 2022Accepted
Number of Pages: 350
Page Range: pp. 325-344
DOI: 10.1016/B978-0-12-823045-9.00029-8
Status: Peer Reviewed
Publication Status: Published
Copyright Holders: Copyright: © Elsevier 2021
Description:

Chapter 19

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