Li, Zehua, Pearce, Amanda K., Du, Jianzhong, Dove, Andrew P. and O'Reilly, Rachel K. (2022) Uniform antibacterial cylindrical nanoparticles for enhancing the strength of nanocomposite hydrogels. Journal of Polymer Science, 359 . 131608. doi:10.1002/pol.20210853 ISSN 2642-4150.

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Abstract

Crystallization-driven self-assembly (CDSA) was employed for the preparation of monodisperse cationic cylindrical nanoparticles with controllable sizes, which were subsequently explored for their effect on antibacterial activity and the mechanical properties of nanocomposite hydrogels. Poly(ɛ-caprolactone)-block-poly(methyl methacrylate)-block-poly[2-(tert-butylamino) ethyl methacrylate] (PCL-b-PMMA-b-PTA) triblock copolymers were synthesized using combined ring-opening and RAFT polymerizations, and then self-assembled into polycationic cylindrical micelles with controllable lengths by epitaxial growth. The polycationic cylinders exhibited intrinsic cell-type-dependent antibacterial capabilities against gram-positive and gram-negative bacteria under physiological conditions, without quaternization or loading of any additional antibiotics. Furthermore, when the cylinders were combined into anionic alginate hydrogel networks, the mechanical response of the hydrogel composite was tunable and enhanced up to 51%, suggesting that cationic polymer fibers with controlled lengths are promising mimics of the fibrous structures in natural extracellular matrix to support scaffolds. Overall, this polymer fiber/hydrogel nanocomposite shows potential as an injectable antibacterial biomaterial, with possible application in implant materials as bacteriostatic agents or bactericides against various infections.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QP Physiology Q Science > QR Microbiology T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Alginates, Colloids, Antibacterial agents, Micelles, Crystallization, Nanocomposites (Materials)
Journal or Publication Title:	Journal of Polymer Science
Publisher:	Wiley-Blackwell Publishing Ltd.
ISSN:	2642-4150
Official Date:	15 May 2022
Dates:	Date Event 15 May 2022 Published 21 February 2022 Available 8 February 2022 Accepted
Volume:	359
Article Number:	131608
DOI:	10.1002/pol.20210853
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	19 April 2022
Date of first compliant Open Access:	21 April 2022
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID UNSPECIFIED China Scholarship Council http://dx.doi.org/10.13039/501100004543 21520710100 Education and Scientific Research Project of Shanghai http://dx.doi.org/10.13039/501100012472 21925505 National Outstanding Youth Science Fund Project of National Natural Science Foundation of China http://dx.doi.org/10.13039/100014717

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