Dean, Samuel (2022) Preprint Highlight : FLAgellum member 8 modulates extravascular trypanosome distribution in the mammalian host. Molecular Biology of the Cell, 33 . 5. doi:10.1091/mbc.p22-02-1006 ISSN 1939-4586.

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Abstract

Trypanosomes are extracellular protozoan parasites that cause human and animal disease. Trypanosomes predominantly inhabit the blood, skin, and adipose tissue and are transmitted by the biting tsetse fly. Little is known of how tissue tropism is regulated or its importance for transmission and pathogenicity. This study investigates FLAM8, a trypanosome flagellar membrane protein of unknown function. The authors show that FLAM8 knockout mutants have normal parasitemia and can differentiate to the transmissible lifecycle stages. However, FLAM8 is required for the parasite to disseminate to the extravascular compartment of the skin, potentially a key point for transmission to new hosts. FLAM8 may therefore be an important player in parasite transmission. This study is of interest to parasitologists studying host–parasite interaction and to cell biologists studying cellular sensing.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor:	Library Publications Router
Journal or Publication Title:	Molecular Biology of the Cell
Publisher:	American Society for Cell Biology (ASCB)
ISSN:	1939-4586
Official Date:	1 May 2022
Dates:	Date Event 1 May 2022 Published
Volume:	33
Article Number:	5
DOI:	10.1091/mbc.p22-02-1006
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)

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