The Library
Synthesis of α- and β-carbolines by a etalation/Negishi cross-coupling/SNAr reaction sequence
Tools
Sathiyalingam, Shainthavaan and Roesner, Stefan (2022) Synthesis of α- and β-carbolines by a etalation/Negishi cross-coupling/SNAr reaction sequence. Advanced Synthesis & Catalysis, 364 (10). pp. 1769-1774. doi:10.1002/adsc.202200127 ISSN 1615-4150.
|
PDF
WRAP-synthesis-α-and-β-carbolines-etalation-Negishi-cross-coupling-SNAr-reaction-sequence-Roesner-2022.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons: Attribution-Noncommercial 4.0. Download (4Mb) | Preview |
Official URL: http://dx.doi.org/10.1002/adsc.202200127
Abstract
A methodology for the synthesis of α- and β-carbolines from fluoropyridines and 2-haloanilines is reported. This procedure consists of a four-step directed ortho-lithiation, zincation, Negishi cross-coupling, and intramolecular nucleophilic aromatic substitution, providing access to a diverse set of functionalized carbolines. While the procedure is applicable to batch conditions, the generation of arylzinc intermediates in continuous flow has been demonstrated.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Palladium , Carbolines, Chemical reactions, Heterocyclic compounds -- Synthesis, Heterocyclic chemistry, Flow chemistry | ||||||||
Journal or Publication Title: | Advanced Synthesis & Catalysis | ||||||||
Publisher: | Wiley-VCH Verlag GMBH | ||||||||
ISSN: | 1615-4150 | ||||||||
Official Date: | 17 May 2022 | ||||||||
Dates: |
|
||||||||
Volume: | 364 | ||||||||
Number: | 10 | ||||||||
Page Range: | pp. 1769-1774 | ||||||||
DOI: | 10.1002/adsc.202200127 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 25 April 2022 | ||||||||
Date of first compliant Open Access: | 27 April 2022 | ||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year