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Condensation of the Drosophila nerve cord is oscillatory and depends on coordinated mechanical interactions
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Karkali, Katerina, Tiwari, Prabhat, Singh, Anand, Tlili, Sham, Jorba, Ignasi, Navajas, Daniel, Muñoz, José J., Saunders, Timothy E. and Martin-Blanco, Enrique (2022) Condensation of the Drosophila nerve cord is oscillatory and depends on coordinated mechanical interactions. Developmental Cell, 57 (7). 867-882.e5. doi:10.1016/j.devcel.2022.03.007 ISSN 1534-5807.
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Official URL: https://doi.org/10.1016/j.devcel.2022.03.007
Abstract
During development, organs reach precise shapes and sizes. Organ morphology is not always obtained through growth; a classic counterexample is the condensation of the nervous system during Drosophila embryogenesis. The mechanics underlying such condensation remain poorly understood. Here, we characterize the condensation of the embryonic ventral nerve cord (VNC) at both subcellular and tissue scales. This analysis reveals that condensation is not a unidirectional continuous process but instead occurs through oscillatory contractions. The VNC mechanical properties spatially and temporally vary, and forces along its longitudinal axis are spatially heterogeneous. We demonstrate that the process of VNC condensation is dependent on the coordinated mechanical activities of neurons and glia. These outcomes are consistent with a viscoelastic model of condensation, which incorporates time delays and effective frictional interactions. In summary, we have defined the progressive mechanics driving VNC condensation, providing insights into how a highly viscous tissue can autonomously change shape and size. [Abstract copyright: Copyright © 2022 Elsevier Inc. All rights reserved.]
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics | |||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Morphogenesis, Drosophila, Central nervous system | |||||||||||||||||||||||||||
Journal or Publication Title: | Developmental Cell | |||||||||||||||||||||||||||
Publisher: | Elsevier | |||||||||||||||||||||||||||
ISSN: | 1534-5807 | |||||||||||||||||||||||||||
Official Date: | 11 April 2022 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 57 | |||||||||||||||||||||||||||
Number: | 7 | |||||||||||||||||||||||||||
Page Range: | 867-882.e5 | |||||||||||||||||||||||||||
DOI: | 10.1016/j.devcel.2022.03.007 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||||||||
Date of first compliant deposit: | 9 May 2022 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 11 April 2023 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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