Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Urinary volatile organic compound testing in fast-track patients with suspected colorectal cancer

Tools
- Tools
+ Tools

Boulind, Caroline E., Gould, Oliver, de Lacy Costello, Ben, Allison, Joanna, White, Paul, Ewings, Paul, Wicaksono, Alfian N., Curtis, Nathan J., Pullyblank, Anne, Jayne, David, Covington, James A., Ratcliffe, Norman, Turner, Claire and Francis, Nader K. (2022) Urinary volatile organic compound testing in fast-track patients with suspected colorectal cancer. Cancers, 14 (9). 2127. doi:10.3390/cancers14092127 ISSN 2072-6694.

[img]
Preview
PDF
WRAP-Urinary-volatile-organic-compound-testing-in-fast-track-patients-with-suspected-colorectal-cancer-Covington-22.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (598Kb) | Preview
Official URL: http://dx.doi.org/10.3390/cancers14092127

Request Changes to record.

Abstract

Colorectal symptoms are common but only infrequently represent serious pathology, including colorectal cancer (CRC). A large number of invasive tests are presently performed for reassurance. We investigated the feasibility of urinary volatile organic compound (VOC) testing as a potential triage tool in patients fast-tracked for assessment for possible CRC. A prospective, multi-center, observational feasibility study was performed across three sites. Patients referred to NHS fast-track pathways for potential CRC provided a urine sample that underwent Gas Chromatography-Mass Spectrometry (GC-MS), Field Asymmetric Ion Mobility Spectrometry (FAIMS), and Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) analysis. Patients underwent colonoscopy and/or CT colonography and were grouped as either CRC, adenomatous polyp(s), or controls to explore the diagnostic accuracy of VOC output data supported by an artificial neural network (ANN) model. 558 patients participated with 23 (4%) CRC diagnosed. 59% of colonoscopies and 86% of CT colonographies showed no abnormalities. Urinary VOC testing was feasible, acceptable to patients, and applicable within the clinical fast track pathway. GC-MS showed the highest clinical utility for CRC and polyp detection vs. controls (sensitivity = 0.878, specificity = 0.882, AUROC = 0.896) but it is labour intensive. Urinary VOC testing and analysis are feasible within NHS fast-track CRC pathways. Clinically meaningful differences between patients with cancer, polyps, or no pathology were identified suggesting VOC analysis may have future utility as a triage tool.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Library of Congress Subject Headings (LCSH): Colon (Anatomy) -- Cancer , Colon (Anatomy) -- Cancer -- Diagnosis, Rectum -- Cancer, Volatile organic compounds
Journal or Publication Title: Cancers
Publisher: MDPI
ISSN: 2072-6694
Official Date: 24 April 2022
Dates:
DateEvent
24 April 2022Published
18 April 2022Accepted
10 March 2022Submitted
Volume: 14
Number: 9
Number of Pages: 12
Article Number: 2127
DOI: 10.3390/cancers14092127
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 9 May 2022
Date of first compliant Open Access: 10 May 2022
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
PB-PG-0416-20022[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us