Thirumoorthy, C., Deepa, M., Srikumar, B. N., Hannah, W., Venkatesan, U., Nikhil, P.J., Hemavathy, S., Binukumar, B., Anjana, R. M., Ram, Uma, Balasubramanyam, M., Saravanan, P., Mohan, V. and Gokulakrishnan, K. (2022) Altered levels of neurobiological biomarkers at the interface of depression and gestational diabetes mellitus in Asian Indian women. Neuropeptides, 93 . 102245. doi:10.1016/j.npep.2022.102245 ISSN 0143-4179.
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Abstract
Aim
Gestational diabetes mellitus (GDM) might predispose the mothers to depression. Studies have reported the role of biomarkers either in GDM or depression, but very few have examined them in GDM with depression. The present study profiled the circulating levels of brain-derived neurotrophic factor (BDNF), Beta Endorphin (BE) and nesfatin-1 in women with GDM (with and without depression).
Methods
160 pregnant women at 24–28 weeks of pregnancy (NGT/GDM with & without depression, n = 40 each) were randomly selected from the ongoing STRiDE (STratification of Risk of Diabetes in Early pregnancy) study. Depression score was derived using PHQ-9 questionnaire and ELISA was used to quantify the biomarkers.
Results
Circulatory levels of BDNF, BE and nesfatin-1 were lower in GDM women with or without depression compared to NGT without depression, however, nesfatin-1 levels were higher in NGT with depression. Notably, GDM with depression had the lowest levels of BDNF and BE. Both BDNF and BE levels were negatively correlated with depression, 1 h and 2 h plasma glucose. Regression analysis confirmed that each standard deviation decreases in BDNF and BE were independently associated with higher odds of GDM with or without depression even after adjusting for potential confounders.
Conclusion
Our study has identified altered levels of a panel of neurobiological biomarkers (BDNF/BE/nesfatin-1) in those with combined GDM and depression. BDNF/BE could be potential biomarkers to assess the higher risk of coexisting depression and GDM.
Item Type: | Journal Article |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
Journal or Publication Title: | Neuropeptides |
Publisher: | Elsevier Ltd. |
ISSN: | 0143-4179 |
Official Date: | June 2022 |
Dates: | Date Event June 2022 Published 20 April 2022 Available 3 April 2022 Accepted 8 February 2022 Submitted |
Volume: | 93 |
Number of Pages: | 7 |
Article Number: | 102245 |
DOI: | 10.1016/j.npep.2022.102245 |
Status: | Peer Reviewed |
Publication Status: | Published |
Access rights to Published version: | Restricted or Subscription Access |
Copyright Holders: | Elsevier Ltd |
URI: | https://wrap.warwick.ac.uk/165313/ |
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