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Vitamin D levels as an important predictor for T2DM and weight regain post-sleeve gastrectomy
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Aladel, Alanoud, Murphy, A. M., Abraham, J., Shah, N., Barber, Thomas M., Ball, G., Menon, V., Piya, M. K. and McTernan, P. G. (2022) Vitamin D levels as an important predictor for T2DM and weight regain post-sleeve gastrectomy. Nutrients, 14 (10). 2052. doi:10.3390/nu14102052 ISSN 2072-6643.
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nutrients-14-02052-v2.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1243Kb) | Preview |
Official URL: https://doi.org/10.3390/nu14102052
Abstract
Weight Loss Surgery (WLS), including sleeve-gastrectomy (SG), results in significant weight loss and improved metabolic health in severe obesity (BMI ≥ 35 kg/m2). Previous studies suggest post-operative health benefits are impacted by nutrient deficiencies, such as Vitamin D (25(OH)D) deficiency, while it is currently unknown whether nutrient levels may actually predict post-surgery outcomes. As such, this study investigated whether 25(OH)D levels could predict metabolic improvements in patients who underwent SG. Patients with severe obesity (n = 309; 75% female) undergoing SG participated in this ethics-approved, non-randomized retrospective cohort study. Anthropometry, clinical data, 25(OH)D levels and serum markers were collected at baseline, 6-, 12- and 18-months post-surgery. SG surgery resulted in significant improvements in metabolic health at 6- and 12-months post-surgery compared with baseline, as expected. Patients with higher baseline 25(OH)D had significantly lower HbA1c levels post-surgery (p < 0.01) and better post-surgical T2DM outcomes, including reduced weight regain (p < 0.05). Further analysis revealed that baseline 25(OH)D could predict HbA1c levels, weight regain and T2DM remission one-year post-surgery, accounting for 7.5% of HbA1c divergence (p < 0.01). These data highlight that higher circulating 25(OH)D levels are associated with significant metabolic health improvements post-surgery, notably, that such baseline levels are able to predict those who attain T2DM remission. This highlights the importance of 25(OH)D as a predictive biomarker of post-surgery benefits.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine |
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| Journal or Publication Title: | Nutrients | ||||||
| Publisher: | MDPI AG | ||||||
| ISSN: | 2072-6643 | ||||||
| Official Date: | 13 May 2022 | ||||||
| Dates: |
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| Volume: | 14 | ||||||
| Number: | 10 | ||||||
| Article Number: | 2052 | ||||||
| DOI: | 10.3390/nu14102052 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 5 July 2022 | ||||||
| Date of first compliant Open Access: | 5 July 2022 |
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