The Library
Can incentives improve antipsychotic adherence in major mental illness? a mixed-methods systematic review
Tools
Tools
Tools
Hodson, Nathan, Majid, Madiha, Vlaev, Ivo and Singh, Swaran P. (2022) Can incentives improve antipsychotic adherence in major mental illness? a mixed-methods systematic review. BMJ Open, 12 (6). e059526. doi:10.1136/bmjopen-2021-059526 ISSN 2044-6055.
|
PDF
WRAP-Can-incentives-improve-antipsychotic-mental-illness-mixed-methods-systematic-review-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (751Kb) | Preview |
|
![[img]](http://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
Can Incentives Improve Antipsychotic Adherence.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (515Kb) |
Official URL: https://doi.org/10.1136/bmjopen-2021-059526
Abstract
Objectives Incentives have been effectively used in several healthcare contexts. This systematic review aimed to ascertain whether incentives can improve antipsychotic adherence, what ethical and practical issues arise and whether existing evidence resolves these issues.
Design Systematic review of MEDLINE, EMBASE and PsycINFO. Searches on 13 January 2021 (no start date) found papers on incentives for antipsychotics. Randomised controlled trials (RCTs), cohort studies, qualitative research and ethical analyses were included. Papers measuring impact on adherence were synthesised, then a typology of ethical and policy issues was compiled, finally the empirical literature was compared with this typology to describe current evidence and identify remaining research questions.
Results 26 papers were included. 2 RCTs used contingent financial incentives for long-acting injectable antipsychotic preparations. Over 12 months, there were significantly larger increases in adherence among the intervention groups versus control groups in both RCTs. There were no consistently positive secondary outcomes. 39 ethical and practical issues were identified. 12 of these are amenable to empirical study but have not been researched and for 7 the current evidence is mixed.
Conclusions In keeping with other areas of healthcare, antipsychotic adherence can be increased with financial incentives. Payments of 2.5 times minimum wage changed behaviour. The typology of issues reported in this systematic review provides a template for future policy and ethical analysis. The persistence of the effect and the impact of incentives on intrinsic motivation require further research.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Social Sciences > Warwick Business School Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||
| Library of Congress Subject Headings (LCSH): | Antipsychotic drugs, Mental illness -- Treatment, Psychoses -- Treatment, Psychopharmacology, Psychotropic drugs, Clinical trials | ||||||
| Journal or Publication Title: | BMJ Open | ||||||
| Publisher: | BMJ | ||||||
| ISSN: | 2044-6055 | ||||||
| Official Date: | 15 June 2022 | ||||||
| Dates: |
|
||||||
| Volume: | 12 | ||||||
| Number: | 6 | ||||||
| Article Number: | e059526 | ||||||
| DOI: | 10.1136/bmjopen-2021-059526 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 13 May 2022 | ||||||
| Date of first compliant Open Access: | 8 July 2022 | ||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
