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Using positional information to provide context for biological image analysis with MorphoGraphX 2.0
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(2022) Using positional information to provide context for biological image analysis with MorphoGraphX 2.0. eLife, 11 . e72601. doi:10.7554/elife.72601 ISSN 2050-084X.
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WRAP-Using-positional-information-provide-context-biological-image-analysis-2022.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (5Mb) | Preview |
Official URL: https://doi.org/10.7554/elife.72601
Abstract
Positional information is a central concept in developmental biology. In developing organs, positional information can be idealized as a local coordinate system that arises from morphogen gradients controlled by organizers at key locations. This offers a plausible mechanism for the integration of the molecular networks operating in individual cells into the spatially-coordinated multicellular responses necessary for the organization of emergent forms. Understanding how positional cues guide morphogenesis requires the quantification of gene expression and growth dynamics in the context of their underlying coordinate systems. Here we present recent advances in the MorphoGraphX software (Barbier de Reuille et al., 2015) that implement a generalized framework to annotate developing organs with local coordinate systems. These coordinate systems introduce an organ-centric spatial context to microscopy data, allowing gene expression and growth to be quantified and compared in the context of the positional information thought to control them.
Item Type: | Journal Article | |||||||||||||||||||||||||||||||||||||||||||||
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Subjects: | Q Science > QH Natural history T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||||||||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Morphogenesis -- Computer simulation, Cells -- Morphology -- Computer simulation, Image processing -- Digital techniques | |||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | eLife | |||||||||||||||||||||||||||||||||||||||||||||
Publisher: | eLife Sciences Publications, Ltd | |||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 2050-084X | |||||||||||||||||||||||||||||||||||||||||||||
Official Date: | 5 May 2022 | |||||||||||||||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 11 | |||||||||||||||||||||||||||||||||||||||||||||
Article Number: | e72601 | |||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.7554/elife.72601 | |||||||||||||||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 24 May 2022 | |||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 24 May 2022 | |||||||||||||||||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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