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Ca2+ regulation of TRP ion channels
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Hasan, Raquibul and Zhang, Xuming (2018) Ca2+ regulation of TRP ion channels. International Journal of Molecular Sciences, 19 (4). 1256. doi:10.3390/ijms19041256 ISSN 1422-0067.
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WRAP-Ca2-regulation-TRP-ion-channels-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (822Kb) | Preview |
Official URL: http://dx.doi.org/10.3390/ijms19041256
Abstract
Ca2+ signaling influences nearly every aspect of cellular life. Transient receptor potential (TRP) ion channels have emerged as cellular sensors for thermal, chemical and mechanical stimuli and are major contributors to Ca2+ signaling, playing an important role in diverse physiological and pathological processes. Notably, TRP ion channels are also one of the major downstream targets of Ca2+ signaling initiated either from TRP channels themselves or from various other sources, such as G-protein coupled receptors, giving rise to feedback regulation. TRP channels therefore function like integrators of Ca2+ signaling. A growing body of research has demonstrated different modes of Ca2+-dependent regulation of TRP ion channels and the underlying mechanisms. However, the precise actions of Ca2+ in the modulation of TRP ion channels remain elusive. Advances in Ca2+ regulation of TRP channels are critical to our understanding of the diversified functions of TRP channels and complex Ca2+ signaling. View Full-Text
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | International Journal of Molecular Sciences | ||||||
Publisher: | MDPI Publishing | ||||||
ISSN: | 1422-0067 | ||||||
Official Date: | 23 April 2018 | ||||||
Dates: |
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Volume: | 19 | ||||||
Number: | 4 | ||||||
Article Number: | 1256 | ||||||
DOI: | 10.3390/ijms19041256 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 17 May 2022 | ||||||
Date of first compliant Open Access: | 17 May 2022 |
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