Hasan, Raquibul and Zhang, Xuming (2018) Ca2+ regulation of TRP ion channels. International Journal of Molecular Sciences, 19 (4). 1256. doi:10.3390/ijms19041256

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Abstract

Ca2+ signaling influences nearly every aspect of cellular life. Transient receptor potential (TRP) ion channels have emerged as cellular sensors for thermal, chemical and mechanical stimuli and are major contributors to Ca2+ signaling, playing an important role in diverse physiological and pathological processes. Notably, TRP ion channels are also one of the major downstream targets of Ca2+ signaling initiated either from TRP channels themselves or from various other sources, such as G-protein coupled receptors, giving rise to feedback regulation. TRP channels therefore function like integrators of Ca2+ signaling. A growing body of research has demonstrated different modes of Ca2+-dependent regulation of TRP ion channels and the underlying mechanisms. However, the precise actions of Ca2+ in the modulation of TRP ion channels remain elusive. Advances in Ca2+ regulation of TRP channels are critical to our understanding of the diversified functions of TRP channels and complex Ca2+ signaling. View Full-Text

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	International Journal of Molecular Sciences
Publisher:	MDPI Publishing
ISSN:	1422-0067
Official Date:	23 April 2018
Dates:	Date Event 23 April 2018 Published 17 April 2018 Accepted
Volume:	19
Number:	4
Article Number:	1256
DOI:	10.3390/ijms19041256
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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