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Calmodulin is responsible for Ca2+-dependent regulation of TRPA1 Channels

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Hasan, Raquibul, Leeson-Payne, Alasdair T. S., Jaggar, Jonathan H. and Zhang, Xuming (2017) Calmodulin is responsible for Ca2+-dependent regulation of TRPA1 Channels. Scientific Reports, 7 (1). 45098 . doi:10.1038/srep45098 ISSN 2045-2322.

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Official URL: http://dx.doi.org/10.1038/srep45098

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Abstract

TRPA1 is a Ca2+-permeable ion channel involved in many sensory disorders such as pain, itch and neuropathy. Notably, the function of TRPA1 depends on Ca2+, with low Ca2+ potentiating and high Ca2+ inactivating TRPA1. However, it remains unknown how Ca2+ exerts such contrasting effects. Here, we show that Ca2+ regulates TRPA1 through calmodulin, which binds to TRPA1 in a Ca2+-dependent manner. Calmodulin binding enhanced TRPA1 sensitivity and Ca2+-evoked potentiation of TRPA1 at low Ca2+, but inhibited TRPA1 sensitivity and promoted TRPA1 desensitization at high Ca2+. Ca2+-dependent potentiation and inactivation of TRPA1 were selectively prevented by disrupting the interaction of the carboxy-lobe of calmodulin with a calmodulin-binding domain in the C-terminus of TRPA1. Calmodulin is thus a critical Ca2+ sensor enabling TRPA1 to respond to diverse Ca2+ signals distinctly.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Calmodulin , TRP channels
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
Official Date: 23 March 2017
Dates:
DateEvent
23 March 2017Published
Volume: 7
Number: 1
Article Number: 45098
DOI: 10.1038/srep45098
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 17 May 2022
Date of first compliant Open Access: 19 May 2022
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDIslamic Development Bankhttp://dx.doi.org/10.13039/501100003971
UNSPECIFIEDCambridge Commonwealth Trusthttp://dx.doi.org/10.13039/501100003342
UNSPECIFIED[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIED[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDRoyal Societyhttp://dx.doi.org/10.13039/501100000288

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