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Targeting TRP ion channels for itch relief
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Zhang, Xuming (2015) Targeting TRP ion channels for itch relief. Naunyn-Schmiedeberg's Archives of Pharmacology, 388 (4). pp. 389-399. doi:10.1007/s00210-014-1068-z
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Official URL: http://dx.doi.org/10.1007/s00210-014-1068-z
Abstract
Acute itch (pruritus) is unpleasant and acts as an alerting mechanism for removing irritants. However, severe chronic itch is debilitating and impairs the quality of life. Rapid progress has been made in recent years in our understanding of the fundamental neurobiology of itch. Notably, several temperature-sensitive transient receptor potential (thermo-TRP) ion channels have emerged as critical players in many types of itch, in addition to pain. They serve as markers that define the itch neural pathway. Thermo-TRP ion channels are thus becoming attractive targets for developing effective anti-pruritic therapies.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Journal or Publication Title: | Naunyn-Schmiedeberg's Archives of Pharmacology | ||||
| Publisher: | Springer | ||||
| ISSN: | 0028-1298 | ||||
| Official Date: | April 2015 | ||||
| Dates: |
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| Volume: | 388 | ||||
| Number: | 4 | ||||
| Page Range: | pp. 389-399 | ||||
| DOI: | 10.1007/s00210-014-1068-z | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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