The Library
The basal thermal sensitivity of the TRPV1 ion channel is determined by PKC II
Tools
Tools
Tools
Li, L., Hasan, R. and Zhang, Xuming (2014) The basal thermal sensitivity of the TRPV1 ion channel is determined by PKC II. Journal of Neuroscience, 34 (24). pp. 8246-8258. doi:10.1523/JNEUROSCI.0278-14.2014
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1523/JNEUROSCI.0278-14.2014
Abstract
Peripheral nociceptors are excited by the activation of membrane receptors and ion channels. The heat-sensitive TRPV1 ion channel responds to various noxious chemical and thermal stimuli, causing pain and itch. Here, we show that TRPV1 is coexpressed with PKCβII in a subset of mouse sensory neurons and that, in these neurons, TRPV1 binds directly to PKCβII, leading to the activation and translocation of PKCβII. Activated PKCβII, in turn, significantly increases the responsiveness of TRPV1 by phosphorylating Thr705. The heat sensitivity of TRPV1 is almost eliminated by either knocking down PKCβII or mutating Thr705; however, neither of these manipulations affects the potentiation of TRPV1 caused by the activation of PKCε. PKCβII thus acts as an auxiliary subunit of TRPV1 by forming a population-dependent TRPV1 ion channel complex controlling the sensitivity of TRPV1 and setting the threshold for pain and itch.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Journal or Publication Title: | Journal of Neuroscience | ||||
| Publisher: | Society for Neuroscience | ||||
| ISSN: | 0270-6474 | ||||
| Official Date: | 11 June 2014 | ||||
| Dates: |
|
||||
| Volume: | 34 | ||||
| Number: | 24 | ||||
| Page Range: | pp. 8246-8258 | ||||
| DOI: | 10.1523/JNEUROSCI.0278-14.2014 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
