Zhang, Xuming, Huang, Jiehong and McNaughton, Peter A. (2005) NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. The EMBO Journal, 24 (24). pp. 4211-4223. doi:10.1038/sj.emboj.7600893

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Abstract

Nociceptors, or pain-sensitive receptors, are unique among sensory receptors in that their sensitivity is increased by noxious stimulation. This process, called sensitization or hyperalgesia, is mediated by a variety of proinflammatory factors, including bradykinin, ATP and NGF, which cause sensitization to noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicin-gated ion channel, TRPV1. Several different mechanisms for sensitization of TRPV1 have been proposed. Here we show that NGF, acting on the TrkA receptor, activates a signalling pathway in which PI3 kinase plays a crucial early role, with Src kinase as the downstream element which binds to and phosphorylates TRPV1. Phosphorylation of TRPV1 at a single tyrosine residue, Y200, followed by insertion of TRPV1 channels into the surface membrane, explains most of the rapid sensitizing actions of NGF.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	The EMBO Journal
Publisher:	Nature Publishing Group
ISSN:	0261-4189
Official Date:	21 December 2005
Dates:	Date Event 21 December 2005 Published
Volume:	24
Number:	24
Page Range:	pp. 4211-4223
DOI:	10.1038/sj.emboj.7600893
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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